Results 81 to 90 of about 4,764,456 (299)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Magnetic moments of W 5d in Ca2CrWO6 and Sr2CrWO6 double perovskites

, 2005
We have investigated the magnetic moment of the W ion in the ferrimagnetic double perovskites Sr2CrWO6 and Ca2CrWO6 by X-ray magnetic circular dichroism (XMCD) at the W L(2,3) edges.
A. Boger, A. Delin, A. Erb, A. Rogalev, F. Wilhelm, G. Vaitheeswaran, J. B. Goodenogh, J. B. Philipp, J. B. Philipp, J. M. Wills, K.-I. Kobayashi, L. Alff, M. Opel, P. Majewski, R. Gross, S. Geprägs, V. Kanchana   +16 more
core   +1 more source

Giant Magnetoresistive Biosensors for Time-Domain Magnetorelaxometry: A Theoretical Investigation and Progress Toward an Immunoassay. [PDF]

, 2017
Magnetorelaxometry (MRX) is a promising new biosensing technique for point-of-care diagnostics. Historically, magnetic sensors have been primarily used to monitor the stray field of magnetic nanoparticles bound to analytes of interest for immunoassays ...
Hall, Drew A, Huang, Chih-Cheng, Zhou, Xiahan   +2 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Non-magnetic impurities in two- and three- dimensional Heisenberg antiferromagnets

, 1996
In this paper we study in a large-S expansion effects of substituting spins by non-magnetic impurities in two- and three- dimensional Heisenberg antiferromagnets in a weak magnetic field.
G. Xiao, H. Alloul, K. Kakurai, K. Uchinokura, M. Azuma, N. Bulut, N. Nagaosa, N. Nagaosa, N. Read, T.K. Ng, Tai-Kai Ng, W. Cheong, Y. Fukuzumi   +12 more
core   +1 more source

Magnetic Pumps [PDF]

, 2013
Micropumps can be classified into two general categories: mechanical and nonmechanical micropumps (an excellent review on micropumps can be found elsewhere [1]). In a typical mechanical pump, a membrane is used to produce the pumping action. Nonmechanical micropumps on the other hand generally have no moving parts.
Çetin, Barbaros, Zeinali, Soheila, Li, D.   +2 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

RC-circuit-like dynamic characteristic of the magnetic domain wall in ferromagnetic nanowires

, 2015
We have investigated dynamic behaviors of the magnetic domain wall under perpendicular magnetic field pulses in ferromagnetic nanowires using micromagnetic simulations.
Cheng Chen, Dong-Hyun Kim, Hong-Guang Piao, Je-Ho Shim, Li-Qing Pan   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Petrographical and geophysical investigation of the Ecca Group between Fort Beaufort and Grahamstown, in the Eastern Cape Province, South Africa

Open Geosciences, 2019
The outcrop of the Ecca Group in the Eastern Cape Province was investigated in order to reveal petrographic and geophysical characteristics of the formations that make up the group which are vital information when considering fracking of the Karoo for ...
Baiyegunhi Christopher, Nxantsiya Zusakhe, Pharoe Kinshasa, Baiyegunhi Temitope L., Mepaiyeda Seyi   +4 more
doaj   +1 more source