Results 41 to 50 of about 355,695 (265)

Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI

NeuroImage, 2020
Odorants can reach olfactory receptor neurons (ORNs) by two routes: orthonasally, when volatiles enter the nasal cavity during inhalation/sniffing, and retronasally, when food volatiles released in the mouth pass into the nasal cavity during exhalation ...
Basavaraju G. Sanganahalli, Keeley L. Baker, Garth J. Thompson, Peter Herman, Gordon M. Shepherd, Justus V. Verhagen, Fahmeed Hyder   +6 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Optimization study on misalignment tolerance of a wireless power transfer system with double-layer vertical DD coils

Wireless Power Transfer
To address the issue of coil misalignment in magnetically coupled wireless power transfer (WPT) systems, which causes fluctuations in mutual inductance, a reduction in the magnetic coupling coefficient, and a decline in transmission efficiency, this ...
Xiaobo Wan, Junwu Jiang, Baoquan Liu
doaj   +1 more source

MAGNETIC CORE APPLICATION IN A PLANAR RESONATOR WITH A YTTRIUM IRON GARNET FILM FOR ENHANCING STRONG PHOTON-MAGNON COUPLING [PDF]

Radio Physics and Radio Astronomy
Subject and Purpose. This paper presents numerical simulation results on the transmission spectra of a split-ring resonator (SRR) loaded with a thin film of yttrium iron garnet (YIG).
A. S. Vakula, S. Yu. Polevoy, K. Yu. Sova, A. A. Girich, S. I. Tarapov, S. V. Nedukh   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Proposal of Fully Integrated LED Driver with Enhanced Power Density for Street-lighting Applications

Eletrônica de Potência
This paper proposes a new fully integrated Boost and Buck converter. The topology results from integrating the Boost as the power factor correction (PFC) stage and the Buck as power control (PC) stage.
Igor B. Barboza, Guirguis Z. Abdelmessih, Renan R. Duarte, Maikel F. Menke, Marco A. D. Costa   +4 more
doaj   +1 more source

Core Loss Analysis and Modeling of a Magnetic Coupling System in WPT for EVs

World Electric Vehicle Journal, 2021
The magnetic core is an important part of the magnetic coupling system in wireless power transmission (WPT) for EVs. It helps to increase the coupling coefficient and reduce magnetic field leakage. However, it also brings additional core loss.
Qingbin Chen, Feng Fan, Jinshuai Wang, Wei Chen   +3 more
doaj   +1 more source

Magnetic core model

IET Science, Measurement & Technology, 2007
The paper presents a nonlinear electric circuit to describe the behaviour of magnetic cores in low-frequency applications. A method of hysteresis modelling is proposed, which is able to reproduce minor loops and remanent flux. Classic eddy-current losses and anomalous losses are represented by a linear resistor and a non linear resistor, respectively ...
F.C.F. Guerra, W.S. Mota
openaire   +1 more source