Results 61 to 70 of about 177,064 (260)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Development and Application of a Gyro Steady-State Drilling Tool

Shiyou jixie, 2023
Due to the formation heterogeneity,unsteady pump rate,high weight on bit and fast rotation,drill strings are associated with multiple kinds of vibration.Severe vibration accelerates the bit failure,increases the tripping operations,and thus impacts the ...
Meng Xiangbo
doaj  

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Magnetization dynamics in magnetically coupled heterostructures [PDF]

, 2009
This thesis focusses on the influence of interlayer coupling on the magnetization dynamics of heterostructure systems. This topic has been investigated by time-resolved photoemission electron microscopy (PEEM) using a pump-probe approach. Magnetic and chemical contrast is provided by the illumination with circularly polarized x-rays due to the x-ray ...
openaire   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

An Anti-Singularity Data-Driven-Control-Based Method for Soft Start and Multi-Machine Balance of Magnetic Couplers

Machines
The speed-regulating magnetic coupler faces challenges in mechanism modeling for constant-torque-load soft start and multi-motor power balance. Moreover, system data contain singular noise values.
Yuqin Zhu, Wei Liu, Hongju Zhao, Chuang Yang, Hao Liu   +4 more
doaj   +1 more source

A Comprehensive Study of Steady-State Modeling Techniques for Magnetic Coupling in DC/DC Converters

IEEE Access
Magnetic coupling is widely employed in multiphase interleaved DC/DC converters owing to its inherent advantages of current ripple reduction and DC flux cancellation.
Xiao Yu, Jens Friebe, Peter Zacharias
doaj   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Nanofiber-reinforced CoFe2O4/graphene composite aerogel as broadband electromagnetic wave absorber

Nano Research
Graphene aerogel (GA) is a promising lightweight and high-performance material for electromagnetic wave absorption due to its ultra-light mass. However, the impedance matching and attenuation capabilities of GA are limited by its high conductivity and ...
Shuang Xu, Qinghai Liu, Zhaoliang Yu, Lijun Li, Xiaodong Dai, Shuyan Yu, Congju Li   +6 more
doaj   +1 more source