Results 241 to 250 of about 24,442 (290)

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Crustal structure of La Palma Island inferred from 3D aeromagnetic modelling. [PDF]

Sci Rep
Romero-Toribio MC, Martín-Hernández F, Ledo J.   +2 more
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Extraordinarily long duration of Eocene geomagnetic polarity reversals. [PDF]

Commun Earth Environ
Yamamoto Y, Boulila S, Takahashi F, Lippert PC.   +3 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Hypomagnetic Fields Influence the Developmental Duration, Fecundity and Temperature Stress Resistance of <i>Drosophila melanogaster</i> via Frataxin-Associated Traits. [PDF]

Biology (Basel)
Kang H, Wan G, Zhang J, Pan W.
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Underground Ferromagnetic Pipeline Detection Using a Rotable Magnetic Sensor Array. [PDF]

Sensors (Basel)
Liu X, Yuan Z, Xia M.
europepmc   +1 more source

A robust edge-detection approach for precise delineation of deep structures from potential field data: Structural insights supported by remote sensing. [PDF]

Sci Rep
Eldosouky AM, Saada SA, Allam SA, El-Gawad AA, Henaish A, Zamzam S.   +5 more
europepmc   +1 more source

Humeral Development Throughout the Arc of Childhood-A 3D MRI Study. [PDF]

J Orthop Res
Lind PM, Pearl ML, Alter KE, Forrest EA, Sheehan FT.   +4 more
europepmc   +1 more source