Results 31 to 40 of about 3,189,782 (241)

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim   +11 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Effects of magnetic ionic liquid as a lubricant on the friction and wear behavior of a steel-steel sliding contact under elevated temperatures

open access: yesFriction, 2019
A magnetic ionic liquid (abridged as MIL) [C6mim]5[Dy(SCN)8] was prepared and used as the magnetic lubricant of a steel-steel sliding pair. The tribological properties of the as-prepared MIL were evaluated with a commercially obtained magnetic fluid ...
Jiajia Jia   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

A Highly Sensitive Magnetic Field Sensor Based on a Tapered Microfiber

open access: yesIEEE Photonics Journal, 2018
A compact all-fiber magnetic field sensor based on the combination of a magnetic fluid and a nonadiabatic microfiber is experimentally demonstrated. By using a fusion splicer combined with an additional flame brushing, the nonadiabatic microfiber, with ...
Zelong Ma   +6 more
doaj   +1 more source

Electrical Conductivity of Field-Structured Emulsions

open access: yesFluids, 2020
The structure formation influence on various macroscopic properties of fluid–fluid disperse systems is poorly investigated. The present work deals with the experimental study of the charge transfer in emulsions whose dispersed phase droplets are arranged
Arthur R. Zakinyan   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Non-dimensional design approach for electrodynamic bearings [PDF]

open access: yes, 2012
Electrodynamic bearings (EDBs) are passive magnetic bearings that exploit the interaction between eddy currents developed in a rotating conductor and a static magnetic field to generate forces. Similar to other types of magnetic suspensions, EDBs provide
Impinna, Fabrizio   +4 more
core  

The behaviour of magnetorheological fluids in squeeze mode [PDF]

open access: yes, 2008
Magnetorheological (MR) fluids possess rheological properties, which can be changed in a controlled way. These rheological changes are reversible and dependent on the strength of an excitation magnetic field.
Bin Mazlan, Saiful Amri
core   +2 more sources

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