Results 41 to 50 of about 229,273 (266)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Polymer-Gel Radiation Dosimetry of Laser-Based Relativistic Electron Sources for Biomedical Applications: First Qualitative Results and Experimental Challenges

Frontiers in Physics, 2022
The generation of laser based relativistic electron sources involves impressive basic science as well as innovative applications. This study reports first novel qualitative results on polymer-gel radiation dosimetry of ultrafast laser-based relativistic ...
Ioannis Fitilis, Ioannis Fitilis, Anastasios Grigoriadis, Anastasios Grigoriadis, Ioannis Tazes, Ioannis Tazes, Stelios Petrakis, Stelios Petrakis, Georgia Andrianaki, Georgia Andrianaki, Vasilios Dimitriou, Vasilios Dimitriou, Efthimios Bakarezos, Efthimios Bakarezos, Emmanouil P. Benis, Emmanouil P. Benis, Irini Tsiapa, Themistoklis Boursianis, Georgios Kalaitzakis, Georgios Bontzos, Georgios Bontzos, Dimitrios A. Liakopoulos, Dimitrios A. Liakopoulos, Evangelos Pappas, Efstathios T. Detorakis, Efstathios T. Detorakis, Eugene L. Clark, Thomas G. Maris, Nektarios A. Papadogiannis, Nektarios A. Papadogiannis, Michael Tatarakis, Michael Tatarakis   +31 more
doaj   +1 more source

Shear Elasticity of Magnetic Gels with Internal Structures

Sensors, 2018
We present the results of the theoretical modeling of the elastic shear properties of a magnetic gel, consisting of soft matrix and embedded, fine magnetizable particles, which are united in linear chain-like structures. We suppose that the composite is placed in a magnetic field, perpendicular to the direction of the sample shear.
Dmitry Borin, Dmitri Chirikov, Andrey Yu Zubarev   +2 more
openaire   +4 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Surface discharge characteristics of silicone gel and DBC under positive repetitive square voltage

Power Electronic Devices and Components, 2022
Silicone gel and direct bonded copper (DBC) as the key components of high voltage power devices are widely used in the insulation packaging of high voltage power devices, respectively.
Chao Li, Boyuan Cao, Xuebao Li, Xiangchen Liu, Jinjin Cheng, Zhaocheng Liu, Zhibin Zhao, Zhongguang Yang   +7 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Bacteria encapsulation in a magnetic sol–gel matrix

Journal of Materials Chemistry, 2009
The encapsulation of Escherichia coli bacteria within ferrihydrite gels favours the long-term viability of the entrapped cells while preserving the magnetic properties of the host material.
Makhlouf, Amoura, Brayner, R., Perullini, Mercedes, Sicard, Clémence, Roux, Clément, Livage, J., Coradin, T.   +6 more
openaire   +3 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source