Results 121 to 130 of about 19,006 (252)

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia

International Journal of Nanomedicine, 2017
Chencai Wang,1 Chao-Hsiung Hsu,1,2 Zhao Li,1 Lian-Pin Hwang,2 Ying-Chih Lin,2 Pi-Tai Chou,2 Yung-Ya Lin1 1Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA; 2Department of Chemistry, National Taiwan University ...
Wang C, Hsu CH, Li Z, Hwang LP, Lin YC, Chou PT, Lin YY   +6 more
doaj  

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Clinical Applications of Electrical Conductivity Imaging Using MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Magnetic resonance imaging (MRI) has emerged as a noninvasive technique for probing the electrical properties of biological tissues: electrical conductivity and relative permittivity. This review focuses on the electrical conductivity and provides a comprehensive overview of applications across both low‐ and high‐frequency regimes.
Stefano Mandija, Khin Khin Tha, Nitish Katoch, Cihan Göksu, Ulrich Katscher, Rosalind Sadleir, Kyu‐Jin Jung, Jierong Luo, Ilias I. Giannakopoulos, Dong‐Hyun Kim, Karin Shmueli, Riccardo Lattanzi, Yusuf Ziya Ider, Axel Thielscher, Cornelis van den Berg   +14 more
wiley   +1 more source

Arsonic Acid Functional Polymers Enable Stabilization of Iron Oxide Nanoparticles in Aqueous Solution

Macromolecular Rapid Communications, EarlyView.
Arsonic acid containing diblock copolymers are developed to incorporate arsonic acid moieties for surface anchoring to IONPs, along with water soluble PEG blocks to impart colloidal stability in aqueous environments. The resulting polymer‐coated IONPs are evaluated for stability in physiological media and cytocompatibility.
Nhu Thao Huynh, Alexander Rajakanthan, Jurie Tashkandi, Rafia Rafique, Milad Ghorbani, Zihnil A. I. Mazrad, Nicole M. Warne, Kiyonori Suzuki, Karen Alt, Paul Wilson, Kristian Kempe   +10 more
wiley   +1 more source

Intratumoral Bacteria: Accomplices in Cancer Progression and Emerging Therapeutic Targets

Medicine Advances, EarlyView.
Intratumoral bacteria are no longer seen as contaminants but as active contributors to cancer progression, driving therapy resistance and metastasis through metabolic reprogramming, immunomodulation, and metastatic niche formation. This review highlights emerging microbiome‐targeted strategies—including synthetic microbial consortia, engineered ...
Jie Yang, Qingyu Han, Qiang Zhang, Yixin Cao   +3 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

International Journal of Nanomedicine, 2018
Dumitru-Daniel Herea,1,* Camelia Danceanu,1,2,* Ecaterina Radu,1,2,* Luminita Labusca,1,3,* Nicoleta Lupu,1,* Horia Chiriac1,* 1MDM Department, National Institute of Research and Development for Technical Physics, Iasi, Romania; 2University “Al I ...
Herea D, Danceanu C, Radu E, Labusca L, Lupu N, Chiriac H   +5 more
doaj  

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Unlocking the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces for adaptive cell modulation

Responsive Materials, EarlyView.
This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of ...
Ruth M. C. Verbroekken, Burcu Gumuscu, Albert P. H. J. Schenning   +2 more
wiley   +1 more source