Results 171 to 180 of about 1,701,138 (265)

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

open access: yesAdvanced Science, Volume 13, Issue 61, 3 November 2026.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li   +8 more
wiley   +1 more source

Cyanopyrazine‐Scaffold Phototheranostic Agents Featuring Type‐I Photosensitization and Photothermal Conversion for Synergistic Tumor Phototherapy

open access: yesAggregate, Volume 7, Issue 11, November 2026.
A family of APzCN‐scaffold type‐I phototheranostic agents by pairing a strongly electron‐deficient acceptor with tunable arylamine donors was developed. The optimized photosensitizer exhibits efficient pure type‐I reactive oxygen species generation and a high photothermal conversion efficiency of 55.1% under 660 nm irradiation, which achieves lysosomal
Xiaoqian Zhang   +8 more
wiley   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu   +4 more
wiley   +1 more source

The Potential for Absolute Temperature Imaging Based on Brain Metabolites Using an FID‐Shifting Approach in Gradient Echo Planar Spectroscopic Imaging (GREPSI)

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 5, Page 2044-2057, November 2026.
ABSTRACT Purpose To implement and evaluate an efficient method for absolute temperature measurement using a gradient echo implementation of the echo planar spectroscopic imaging (EPSI) sequence. Methods The gradient echo EPSI sequence (GREPSI) utilizes an oscillating readout gradient together with continuous signal readout after slab selective ...
Dennis L. Parker   +5 more
wiley   +1 more source

Engineering Safety Through MOFs‐Based Nanocomposites: Advances in Design, Fabrication, and Deployment Across Emerging Domains

open access: yesRare Metals, Volume 45, Issue 11, November 2026.
ABSTRACT Ensuring uncompromised safety across interconnected domains is vital for global societal sustainability. Metal–organic framework (MOF)‐based nanocomposites, owing to their intrinsically tunable structures and broad functional versatility, represent a powerful class of materials for safety‐related engineering.
Rongfu Peng   +6 more
wiley   +1 more source

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