Results 21 to 30 of about 883,127 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multiparametric robust sensing via readout of characteristic magnetization loops

Scientific Reports
Simultaneous measurements of multiple physical quantities under variable conditions are essential from fundamental research to application. However, multiparametric sensors often need intricate calibration procedures which can be compromised by changing ...
Michael P. Path, Michael Vogel, Jeffrey McCord   +2 more
doaj   +1 more source

Effect of Ge doping on the magnetic properties of Fe-6.5Si soft magnetic composites

Journal of Materials Research and Technology, 2023
In this work, the effect of Ge content on the soft magnetic properties and microstructure of FeSiGe soft magnetic powder cores (SMPCs) was systematically investigated.
Xubin Li, Jianjun Huang, Yaqiang Dong, Xincai Liu, Ronglin Zhao, Shouding Wu, Hang Wu, Wei Gao, Aina He, Jiawei Li   +9 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Tomography-based digital twin of Nd-Fe-B permanent magnets

npj Computational Materials
Many functional materials have been designed at the multiscale level. To properly simulate their physical properties, large and sophisticated computer models that can replicate microstructural features with nanometer-scale accuracy are required.
Anton Bolyachkin, Ekaterina Dengina, Nikita Kulesh, Xin Tang, Hossein Sepehri-Amin, Tadakatsu Ohkubo, Kazuhiro Hono   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Quantitative magnetooptical analysis using indicator films for the detection of magnetic field distributions, temperature, and electrical currents

Scientific Reports
The accurate characterization of local magnetic fields and temperature is vital for the design of electronic systems. To meet this imperative, we present a novel non-contact approach for simultaneous quantitative magnetic field imaging and temperature ...
Michael P. Path, Jeffrey McCord
doaj   +1 more source

Magnetic anisotropy and high-frequency property of flexible FeCoTa films obliquely deposited on a wrinkled topography

Scientific Reports, 2017
We investigated the magnetic anisotropy and the high-frequency property of flexible Fe60Co26Ta14 (FeCoTa) thin films obtained by oblique sputtering onto a wrinkled surface.
Jincai Li, Qingfeng Zhan, Shuanglan Zhang, Jinwu Wei, Jianbo Wang, Minjie Pan, Yali Xie, Huali Yang, Zheng Zhou, Shuhong Xie, Baomin Wang, Run-Wei Li   +11 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

High-field flux jump instabilities in cables for accelerator or compact fusion magnets and their effective suppression

Scientific Reports
Rare-earth-barium-copper-oxide (ReBCO) superconducting tapes are pivotal for emerging technologies such as fusion reactors and particle accelerators due to their superior performance in high magnetic fields. Despite extensive studies of single tapes, the
Tushar Garg, Mike D. Sumption, Milan Majoros, Edward Collings, Jan Jaroszynski, Eun-Sang Choi   +5 more
doaj   +1 more source