Results 51 to 60 of about 258,747 (280)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Magnetic Particle Imaging–Guided Stenting

Journal of Endovascular Therapy, 2019
Purpose:To assess the feasibility of magnetic particle imaging (MPI) to guide stenting in a phantom model. Materials and Methods: MPI is a new tomographic imaging method based on the background-free magnetic field detection of a tracer agent composed of superparamagnetic iron oxide nanoparticles (SPIOs).
Stefan Herz, Patrick Vogel, Thomas Kampf, Philipp Dietrich, Simon Veldhoen, Martin A. Rückert, Ralph Kickuth, Volker C. Behr, Thorsten A. Bley   +8 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Multidimensional X-Space Magnetic Particle Imaging [PDF]

IEEE Transactions on Medical Imaging, 2011
Magnetic particle imaging (MPI) is a promising new medical imaging tracer modality with potential applications in human angiography, cancer imaging, in vivo cell tracking, and inflammation imaging. Here we demonstrate both theoretically and experimentally that multidimensional MPI is a linear shift-invariant imaging system with an analytic point spread
Patrick W, Goodwill, Steven M, Conolly
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Development of a new Thomson parabola spectrometer for analysis of laser accelerated ions [PDF]

, 2020
This thesis details my work on developing a new Thomson parabola spectrometer for use at the SCARLET Laser Facility at The Ohio State University. The SCARLET laser facility is a 300 TW laser reaching peak intensities exceeding 10 21 W/cm 2 .
Winter, Connor
core  

Controlled biomineralization of magnetite (Fe₃O₄) by Magnetospirillum gryphiswaldense [PDF]

, 2008
Results from a study of the chemical composition and micro-structural characteristics of bacterial magnetosomes extracted from the magnetotactic bacterial strain Magnetospirillum gryphiswaldense are presented here.
Bauerlein, Bazylinski, Bazylinski, C. Moisescu, D. Tobler, I. Ardelean, L. G. Benning, Lang, Lowenstam, Meldrum, Posfai, S. Bonneville, Weiner   +12 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.

PLoS ONE, 2013
BackgroundIron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve ...
Lucas W E Starmans, Dirk Burdinski, Nicole P M Haex, Rik P M Moonen, Gustav J Strijkers, Klaas Nicolay, Holger Grüll   +6 more
doaj   +1 more source

Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Molecular Imaging, 2023
Magnetic particle imaging (MPI) is a new tracer-based imaging modality that is useful in diagnosing various pathophysiology related to the vascular system and for sensitive tracking of cytotherapies.
Prashant Chandrasekharan, Renesmee Kuo, K. L. Barry Fung, Chinmoy Saayujya, Jacob Bryan, Mariam Yousuf, Benjamin Fellows, Caylin Colson, Quincy Huynh, Owen Doyle, Allison Hartley, Khadija Yousuf, Patrick Goodwill, Steven Conolly   +13 more
doaj   +1 more source