Results 71 to 80 of about 2,633,866 (292)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Integration of carboxyl modified magnetic particles and aqueous two-phase extraction for selective separation of proteins

, 2011
Integration of carboxyl modified magnetic particles and aqueous two-phase extraction for selective separation of proteinsBoth of the magnetic particle adsorption and aqueous two-phase extraction (ATPE) were simple, fast and low-cost method for protein ...
Gai, Qingqing, Qu, Feng, 张玉奎, Zhang, Yukui, 屈锋, Zhang, Tao   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Experimental research on the deep reduction-magnetic separation of ironsand

工程科学学报, 2016
The basic characteristics of ironsand were systematically studied by chemical analysis, scanning electron microscopy and X-ray diffraction. A series of experiments were performed to investigate reduction-magnetic separation for Fe and Ti from iron-sand ...
LIU Yi-ran, ZHANG Jian-liang, WANG Zhen-yang, LIU Zheng-jian, XING Xiang-dong   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Efficiency of high gradient magnetic separation applied to micrometric magnetic particles

, 2015
This article presents two prototypes of laboratory magnetic separators that generate high gradient magnetic fields. Such a field is created in a separation cell via steel wool.
Lesňák, Michal, Seidlerová, Jana, Luňáček, Jiří, Dvorský, Richard, J. Repkova (763439), P. Jandacka (763437), Repková, Jana, R. Dvorsky (763438), Vítkovská, Nikola, M. Lesnak (763436), N. Vitkovska (763441), J. Lunacek (763435), Jandačka, Petr, J. Seidlerova (763440)   +13 more
core   +1 more source

Rare-earth separations enhanced by magnetic field

, 2022
The separation of rare earth (RE) elements is a challenge from their discovery to the present day, due to the chemical and physical similarities as a group. The intrinsic properties of REs are basic for separation mechanisms.
Cheng, Yanyan, Zhang, Xiangping, Fan, Bangyu, Li, Fujian, Zhang, Nian, Bai, Lu, Wu, Qingrong, Wang, Zhongzhi   +7 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source