Results 141 to 150 of about 106,203 (290)
Advanced Science, EarlyView.Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li +8 more
wiley +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.A brain‐adhesive sensor (B‐Sensor) was developed by integrating a self‐healing biodegradable elastomer, a tissue‐adhesive hydrogel, and molybdenum electrodes. The B‐Sensor adheres to brain tissue, conforms to cortical curvatures, and maintains stable electrical performance over the intended period for reliable recording of spatiotemporal brain activity
Heewon Choi +8 more
wiley +1 more source
A study of geomagnetic storms [PDF]
Twenty-one geomagnetic storm events during 1966 and 1970 were studied by using simultaneous interplanetary magnetic field and plasma parameters. Explorer 33 and 35 field and plasma data were analyzed on large-scale (hourly) and small-scale (3 min ...
Patel, V. L.
core +1 more source
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
Advanced Science, EarlyView.This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin +2 more
wiley +1 more source
Plasma wave observations near the plasmapause with the S3-A satellite [PDF]
The electric field noise phenomena is described which was observed by the S3-A spacecraft near the plasmapause during the magnetic storm of 16 to 17 December, 1971.
Anderson, R. R., Gurnett, D. A.
core +1 more source
Advanced Science, EarlyView.A Lewis pair site design strategy was established to construct Cu‐doped Mn‐based amorphous nanozymes, where Mn and oxygen vacancies generate cooperative acid‐base pairs. The resulting multinanozyme integrates glycosidase‐, oxidase‐, and cold‐adapted enzyme‐mimicking activities, enabling cooperative depolymerization of cellulose and hemicellulose ...
Huile Liu +8 more
wiley +1 more source
Geophysical Research LettersWe report a citizen science‐motivated study on the cause of an unusually bright red aurora as witnessed from Hokkaido, Japan during a magnetic storm on 1 December 2023. The auroral brightness of 5 kR is unusual for the Dst index peak of only −107 nT.
Ryuho Kataoka +6 more
doaj +1 more source
Boosting Photo‐Pyroelectric Effect via Tunable Polarization and Interfacial Defect Engineering
Advanced Science, EarlyView.This study reports Ba(Ti0.85Zr0.15)O3 nanocatalysts with enhanced polarization and oxygen‐vacancy‐rich interfaces for efficient NIR‐II photo‐pyroelectric therapy. Zr doping boosts the pyroelectric coefficient and accelerates polarization switching, while oxygen vacancies improve photothermal conversion and surface reactivity.
Yanli Huang +13 more
wiley +1 more source