Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Seismic stratigraphy and marine magnetics of the Naples Bay (Southern Tyrrhenian sea, Italy): the onset of new technologies in marine data acquisition, processing and interpretation [PDF]
Seismic stratigraphy and marine magnetics in the case histories of the Somma-Vesuvius volcanic complex, Phlegrean Fields offshore and Ischia and Procida islands offshore (Naples Bay, Southern Tyrrhenian sea) are here discussed.
Aiello, Gemma +7 more
core +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Charity Shoal structure is a circular, ∼1.2‐km‐diameter, bedrock‐rimmed shoal in eastern Lake Ontario with a ∼20‐m‐deep central basin. The structure has been proposed as a possible Middle Ordovician impact crater or volcanic intrusion.
Mary H. Armour +3 more
doaj +1 more source
A Review of Tunable Inductors for Power Electronics: Techniques and Applications
Magnetic components are recently being researched and believed to be a main source of losses, and increasing the weight of power converters, which has become a real challenge for designers.
Raheem Elsayed A․ Azim
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Magnetic Noise in Structured Hard Magnets [PDF]
The anomalous Hall effect of wires patterned from (Co{90}Fe{10}/Pt){n} multilayers, with ...
Zhu, Diao +3 more
openaire +5 more sources
Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant
Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke +9 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source

