Results 51 to 60 of about 34,301 (268)
Wideband Millimeter-Wave Perforated Cylindrical Dielectric Resonator Antenna Configuration
MagnetismThis article delves into the capabilities of 3D-printed millimeter-wave (mmWave) layered cylindrical dielectric resonator antennas (CDRAs). The proposed design yielded promising results, boasting a remarkable 53% impedance bandwidth spanning the ...
Waled Albakosh +4 more
doaj +1 more source
Magnetization transfer in magnetic resonance fingerprinting
Magnetic Resonance in Medicine, 2019 PurposeTo study the effects of magnetization transfer (MT, in which a semi‐solid spin pool interacts with the free pool), in the context of magnetic resonance fingerprinting (MRF).MethodsSimulations and phantom experiments were performed to study the impact of MT on the MRF signal and its potential influence on T1 and T2 estimation.
Tom Hilbert +7 more
openaire +5 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Correlation of Light Polarization in the Magnetic Media with Non-Spherical Point-Like Inclusions
Magnetism, 2022 Light propagation through magnetic media with ellipsoidal inclusions much smaller than the light wavelength was investigated theoretically. It is assumed that the ellipsoidal inclusions have the same orientation but are randomly distributed inside the ...
Ramil A. Niyazov +2 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
, 2013 Micropumps can be classified into two general categories: mechanical and nonmechanical micropumps (an excellent review on micropumps can be found elsewhere [1]). In a typical mechanical pump, a membrane is used to produce the pumping action. Nonmechanical micropumps on the other hand generally have no moving parts.
Çetin, Barbaros +2 more
openaire +2 more sources