Results 71 to 80 of about 246,356 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Automated High-Speed Approaches for the Extraction of Permanent Magnets from Hard-Disk Drive Components for the Circular Economy

Magnetism
This work describes an automated pilot plant for the extraction of rare-earth (RE) permanent magnets from computer hard-disk drives (HDDs), demonstrating a commercially viable way to exploit these abundant sources of end-of-life (EOL) magnets.
Carlo Burkhardt, Francisco Ortiz, Kaies Daoud, Tomas Björnfot, Fredrik Ahrentorp, Jakob Blomgren, Allan Walton   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhancing Magnetic Coupling Using Auxiliary Short-Circuited Coils

Magnetism
The efficiency of Dynamic Inductive Power Transfer (DIPT) depends mainly on the coupling coefficient within the coupler. In order to improve this parameter, a novel approach has been introduced that results in a significant increase of between 25% and 36%
Tanguy Phulpin, Wassim Kabbara, Mohammed Terrah, Mostafa-Kamel Smail, Mohamed Bensetti   +4 more
doaj   +1 more source

MuSR studies of RE(O,F)FeAs (RE = La, Nd, Ce) and LaOFeP systems: possible incommensurate/stripe magnetism and superfluid density

, 2008
Muon spin relaxation (MuSR) measurements in iron oxy-pnictide systems have revealed: (1) commensurate long-range order in undoped LaOFeAs; (2) Bessel function line shape in La(O0.97F0.03)FeAs which indicates possible incommensurate or stripe magnetism ...
Carlo, J. P., Chen, G. F., Dai, Pengcheng, Goko, T., Hu, W. Z., Luke, G. M., Luo, J. L., MacDougall, G. J., Miyasaka, S., Rodriguez, J. A., Shannon, N., Suzuki, S., Tajima, S., Uemura, Y. J., Wang, N. L., Yu, W.   +15 more
core   +1 more source

Magnetic Pumps [PDF]

, 2013
Micropumps can be classified into two general categories: mechanical and nonmechanical micropumps (an excellent review on micropumps can be found elsewhere [1]). In a typical mechanical pump, a membrane is used to produce the pumping action. Nonmechanical micropumps on the other hand generally have no moving parts.
Çetin, Barbaros, Zeinali, Soheila, Li, D.   +2 more
openaire   +2 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source