Results 51 to 60 of about 1,503,596 (264)
Dedicated comparatives aid comparisons of magnitude: a study with Pitjantjatjara-English bilinguals
Frontiers in Human NeuroscienceWhen expressing comparisons of magnitude, Pitjantjatjara, a language indigenous to the land now known as Australia, employs contextually driven comparators (e.g., Anyupa is tall.
Luke Greenacre +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dizhen xuebao, 2018 本文针对2008年5月12日四川汶川MW7.9地震后的余震目录，采用2004年Shcherbakov和Turcotte提出的最大余震震级推断法，给出了最大余震震级的估计值。结果表明，采用现有的余震数据，在大震级区间可能存在一定数量的余震缺失，这造成了余震数据与Gutenberg-Richter定律曲线在大震级区间的差异，导致推断的最大余震震级与使用目录中的最大余震震级存在明显差异。利用震级与断层长度或地表破裂长度之间的经验关系可以看出，由灌县—江油断裂的破裂尺度得到的震级与推断最大余震震级基本一致 ...
Mengyu Xie, Baoping Shi
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The cause of high intensity of seismicity in Ukraine
Вісник Київського національного університету імені Тараса Шевченка. Серія Геологія, 2018 In the article, the earthquake near Sumy is considered in detail. According to the authors, this earthquake occurred under the influence of several stress regimes.
O. Chalyi +7 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
A severe 2017 influenza season dominated by influenza A(H3N2), Victoria, Australia
Western Pacific Surveillance and Response, 2018 Surveillance for influenza-like illness (ILI) and laboratory-confirmed influenza in Victoria, Australia is undertaken jointly by the Victorian Infectious Diseases Reference Laboratory and the Victorian Government Department of Health and Human Services ...
Kristina Grant +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source