Results 71 to 80 of about 5,334,300 (298)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Conditional Colour-Magnitude Distribution: I. A Comprehensive Model of the Colour-Magnitude-Halo Mass Distribution of Present-Day Galaxies

, 2018
We formulate a model of the conditional colour-magnitude distribution (CCMD) to describe the distribution of galaxy luminosity and colour as a function of halo mass. It consists of two populations of different colour distributions, dubbed pseudo-blue and
Guo, Hong, Weinberg, David H., Xu, Haojie, Zehavi, Idit, Zheng, Zheng, Zu, Ying   +5 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A High Relative-Precision Color-Magnitude Diagram of M67

, 2003
We have calibrated an extensive set of BVI observations of M67. We have selected stars that are most likely to be single-star members of the cluster using proper motion, radial velocity, and variability information from the literature, and an examination
Alexander, Aparicio, Balachandran, Baraffe, Baume, Belikov, Belloni, Bergeron, Bessell, Bessell, Bressan, Brown, Castelli, Chabrier, Chevalier, Dinescu, Eric L. Sandquist, Fan, Gilliland, Gilroy, Girard, Girardi, Girardi, Gratton, Green, Hobbs, Honeycutt, Houdashelt, Janes, Joner, Jones, Kurucz, Kurucz, Landolt, Lejeune, Lejeune, Maeder, Mathieu, Mathieu, Mathieu, Melo, Mihalas, Montgomery, Percival, Richer, Rogers, Roxburgh, Rucinski, Sanders, Sandquist, Sandquist, Sandquist, Sarajedini, Saumon, Shetrone, Soderblom, Stassun, Stetson, Stetson, Stetson, Stetson, van den Berg, van den Berg, von Hippel, Wilden, Woo, Woo, Yi, Zhao   +68 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

对汶川地震余震序列中最大余震事件的讨论

Dizhen xuebao, 2018
本文针对2008年5月12日四川汶川MW7.9地震后的余震目录，采用2004年Shcherbakov和Turcotte提出的最大余震震级推断法，给出了最大余震震级的估计值。结果表明，采用现有的余震数据，在大震级区间可能存在一定数量的余震缺失，这造成了余震数据与Gutenberg-Richter定律曲线在大震级区间的差异，导致推断的最大余震震级与使用目录中的最大余震震级存在明显差异。利用震级与断层长度或地表破裂长度之间的经验关系可以看出，由灌县—江油断裂的破裂尺度得到的震级与推断最大余震震级基本一致 ...
Mengyu Xie, Baoping Shi
doaj   +1 more source

Activity Recognition based on a Magnitude-Orientation Stream Network

, 2017
The temporal component of videos provides an important clue for activity recognition, as a number of activities can be reliably recognized based on the motion information.
Caetano, Carlos, de Melo, Victor H. C., Santos, Jefersson A. dos, Schwartz, William Robson   +3 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Sublime in Its Magnitude : The Emancipation Proclamation

, 2007
Book Summary: Lincoln’s reelection in 1864 was a pivotal moment in the history of the United States. The Emancipation Proclamation had officially gone into effect on January 1, 1863, and the proposed Thirteenth Amendment had become a campaign issue ...
Guelzo, Allen C.
core