Results 91 to 100 of about 2,455,254 (309)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Diffraction gratings with two-orders-of-magnitude-enhanced dispersion rates for sub-meV-resolution soft x-ray spectroscopy

, 2020
Diffraction gratings with large angular dispersion rates are central to obtaining high spectral resolution in grating spectrometers operating over a broad spectral range from infrared to soft-x-ray domains.
Yuri Shvyd'ko (14412468)
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Medication Administration Errors and Associated Factors Among Nurses

International Journal of General Medicine, 2020
Dejene Tsegaye,1 Girma Alem,1 Zenaw Tessema,2 Wubet Alebachew3 1Department of Nursing, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos,
Tsegaye D, Alem G, Tessema Z, Alebachew W   +3 more
doaj  

plasticityai/magnitude: Release 0.0.20

, 2018
A fast, efficient universal vector embedding utility ...
Ajay Patel
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Comparative Analysis Of Accelerometer Sensor And Piezoelectric Sensor Capabilities In The Early Warning System Earthquake Disaster

Journal of Electrical Engineering and Computer
An earthquake is a vibration or shock caused by a sudden release of energy from within the earth, which produces seismic waves. The Indonesian region is currently vulnerable to volcanic and tectonic earthquakes due to the Pacific Ring of Fire, where the ...
Yoses Manuel, Kartiko Ardi Widodo, Bima Romadhon Palevi   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Magnitude and associated factors of neonatal mortality among neonates admitted at Dessie comprehensive specialized hospital, Northeast, Ethiopia

Frontiers in Pediatrics
BackgroundNeonatal mortality rate is high in sub-Saharan Africa than high-income countries in relation to the growing wealth disparity. Different factors are linked with neonatal mortality in Ethiopia.
Berhanu Adugna, Robel Asaminew, Getye Solomon Maru, Haimanot Ayele Eshetie, Endris Mohammed, Ayele Samuel, Abdulmelik Mekonnnen, Nurye Fentaw, Brhanu Belay, Adem Mekonen, Mengstie Nigussie, Fekadeselassie Belege Getaneh, Alemu Gedefie   +12 more
doaj   +1 more source