Results 91 to 100 of about 2,113,384 (312)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Dizhen xuebao, 2018 本文针对2008年5月12日四川汶川MW7.9地震后的余震目录，采用2004年Shcherbakov和Turcotte提出的最大余震震级推断法，给出了最大余震震级的估计值。结果表明，采用现有的余震数据，在大震级区间可能存在一定数量的余震缺失，这造成了余震数据与Gutenberg-Richter定律曲线在大震级区间的差异，导致推断的最大余震震级与使用目录中的最大余震震级存在明显差异。利用震级与断层长度或地表破裂长度之间的经验关系可以看出，由灌县—江油断裂的破裂尺度得到的震级与推断最大余震震级基本一致 ...
Mengyu Xie, Baoping Shi
doaj +1 more source
A Magnitude Effect in Temporal discounting with Hens
, 2014 This study aimed to determine whether a magnitude effect could be obtained in temporal discounting with brown shaver hens. Subjects responded in a classic self-control situation for the choice between a smaller-sooner reward (1-s access to food, after a ...
Budenberg, Grace Joy
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Magnitude calibration of the seismographic sub-network in NW Saudi Arabia
, 2000 Seismic Studies Center, King Saud University, Riyadh, Saudi ArabiaTwo magnitude formulas to be applied in seismic parameter determinations were developed for the seismographic sub-network in NW Saudi Arabia: ML = Log (A / T) + 3.4 Log D + 2.55 and Mc = 2.
Uy, E.A., Punsalan, B.T., Al-Amri, A. M.
core
The Relationship between Force Magnitude and Optimum Tooth Movement [PDF]
, 2007 The force applied on the tooth and the consequential tooth movement has been a popular topic for orthodontists for many years. In this article, force magnitude, optimal tooth movement and their relationship will be discussed.
Cihan Çapan +3 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Magnitude-based inference analysis between-groups.
, 2016 Trivial area (grey) threshold is -0.2 to 0.2 and bars indicate ±90% confidence limits. AD = absolute decrement; BT = best time; DP = decrement percentage; MT = mean time; RSA1 = RSA test performed before T30; RSA2 = RSA test performed after T30; TT ...
Marcelo Papoti (3387707) +3 more
core +1 more source