Results 101 to 110 of about 5,334,300 (298)

Russian economy: challenges and reaction

Путеводитель предпринимателя
The article examines and analyzes the problems and dynamics of economic growth in 2024 under the influence of external and internal factors and conditions, the dynamics of the key interest rate and inflation, and ways to reduce the volatility of the ...
L. A. Akhmetov, M. A. Bulavina
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Magnitude and associated factors of neonatal mortality among neonates admitted at Dessie comprehensive specialized hospital, Northeast, Ethiopia

Frontiers in Pediatrics
BackgroundNeonatal mortality rate is high in sub-Saharan Africa than high-income countries in relation to the growing wealth disparity. Different factors are linked with neonatal mortality in Ethiopia.
Berhanu Adugna, Robel Asaminew, Getye Solomon Maru, Haimanot Ayele Eshetie, Endris Mohammed, Ayele Samuel, Abdulmelik Mekonnnen, Nurye Fentaw, Brhanu Belay, Adem Mekonen, Mengstie Nigussie, Fekadeselassie Belege Getaneh, Alemu Gedefie   +12 more
doaj   +1 more source

Scaling relation between earthquake magnitude and the departure time from P wave similar growth

Geophysical Research Letters, 2016
We introduce a new scaling relation between earthquake magnitude (M) and a characteristic of initial P wave displacement. By examining Japanese K‐NET data averaged in bins partitioned by Mw and hypocentral distance, we demonstrate that the P wave ...
Shunta Noda, William L. Ellsworth
doaj   +1 more source

RECENT STRONG EARTHQUAKES IN CENTRAL ASIA: REGULAR TECTONOPHYSICAL FEATURES OF LOCATIONS IN THE STRUCTURE AND GEODYNAMICS OF THE LITHOSPHERE. PART 1. MAIN GEODYNAMIC FACTORS PREDETERMINING LOCATIONS OF STRONG EARTHQUAKES IN THE STRUCTURE OF THE LITHOSPHER

Геодинамика и тектонофизика, 2015
Studying locations of strong earthquakes (М≥8) in space and time in Central Asia has been among top prob-lems for many years and still remains challenging for international research teams.
S. I. Sherman, Ma Jin, E. A. Gorbunova
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Earthquake Swarm Activity in the Tokara Islands (2025): Statistical Analysis Indicates Low Probability of Major Seismic Event

GeoHazards
The Tokara Islands, a volcanic archipelago located south of Japan’s main islands, experienced earthquake swarm activity in 2025. Public concern has emerged regarding the potential triggering of the anticipated Nankai Trough earthquake, which the Japan ...
Tomokazu Konishi
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source