Results 101 to 110 of about 2,113,384 (312)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Prevalence of Ear Nose and Throat (ENT) Manifestations Among HIV Seropositive Patients at a Tertiary Hospital in Northern Tanzania: A Descriptive Cross-Sectional Study

HIV/AIDS: Research and Palliative Care, 2020
Peter Stephen Shija,1,2 Joshua Alexander Karaba,1,2 Rune Nathaniel Philemon,1,3 Bernard Lucas Minja,1 Philbert Patrick Mtenga,1,2 Denis Robert Katundu1,2 1Kilimanjaro Christian Medical Center Moshi (KCMC), Moshi, Tanzania; 2Department of Ear Nose and ...
Shija PS, Karaba JA, Philemon RN, Minja BL, Mtenga PP, Katundu DR   +5 more
doaj  

Diffraction gratings with two-orders-of-magnitude-enhanced dispersion rates for sub-meV-resolution soft x-ray spectroscopy

, 2020
Diffraction gratings with large angular dispersion rates are central to obtaining high spectral resolution in grating spectrometers operating over a broad spectral range from infrared to soft-x-ray domains.
Yuri Shvyd'ko (14412468)
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

plasticityai/magnitude: Release 0.0.20

, 2018
A fast, efficient universal vector embedding utility ...
Ajay Patel
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Magnitude-frequency aspects of alpine debris flows

, 1997
Based on historic documents the event history for 17 mountain torrents in the Swiss Alps was evaluated. Four classes could be determined for the recurrence interval of the debris flow events.
Zimmermann, Markus N., Mani, Peter, Romang, Hans   +2 more
core   +1 more source

Salience versus magnitude in the measurement of the cortisol awakening response [PDF]

, 2019
Pulsatile ultradian secretion of cortisol, rarely studied in salivary data, has functional importance in hypothalamic pituitary adrenal (HPA) axis regulation.
Evans, P., Thorn, L., Smyth, N., Hucklebridge, F., Clow, A.   +4 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Medication Administration Errors and Associated Factors Among Nurses

International Journal of General Medicine, 2020
Dejene Tsegaye,1 Girma Alem,1 Zenaw Tessema,2 Wubet Alebachew3 1Department of Nursing, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos,
Tsegaye D, Alem G, Tessema Z, Alebachew W   +3 more
doaj