Results 111 to 120 of about 5,334,300 (298)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Prevalence and associated factors of self-medication among pregnant women in Sodo Town, Southern Ethiopia

Frontiers in Medicine
BackgroundSelf-medication is a widespread practice among pregnant women worldwide, with 44.55% practicing it. However, it may lead to incorrect diagnosis, inappropriate treatment, and failure to recognize contraindications.
Mesfin Abebe, Silenat Gashaw, Dinkalem Getahun, Wudit Wassu, Tiruye Menshaw, Serawit Lakew   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reassessing the Location, Magnitude, and Macroseismic Intensity Map of the 8 April 1893 Svilajnac (Serbia) Earthquake

Applied Sciences
A devastating earthquake took place on 8 April 1893, close to the town of Svilajnac, central Serbia. Over the past decade, significant historical data on the effects of this earthquake has been collected from a variety of sources, including books ...
Miodrag I. Manić, Borko Đ. Bulajić
doaj   +1 more source

Bidirectional modulation of numerical magnitude [PDF]

, 2015
Arshad, Q, Bronstein, A
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Long-Term Correlations in São Francisco River Flow: The Influence of Sobradinho Dam

Revista Brasileira de Meteorologia
In this work we study the influence of the Sobradinho dam construction on daily streamflow of São Francisco River, Brasil, by analyzing long-range correlations in magnitude and sign time series obtained from streamflow anomalies, using the Detrended ...
Ikaro Daniel de Carvalho Barreto, Silvio Fernando Alves Xavier Junior, Tatijana Stosic   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

When speaking of the experience, do not leave out the experiencer: on self and magnitude

Frontiers in Psychology, 2013
Shahar eArzy, Shahar eArzy
doaj   +1 more source

Precipitation extremes projected to increase and to occur in different times of the year

Environmental Research Letters
There is high confidence that precipitation extremes are projected to become more frequent and severe and, to a lesser extent, that their seasonality may change.
Dario Treppiedi, Gabriele Villarini, Jens Bender, Leonardo Valerio Noto   +3 more
doaj   +1 more source