Results 41 to 50 of about 5,473 (218)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Expanding Moment Magnitude Pools for Earthquake Magnitude Homogenization
Applied Sciences, 2022 A comparison on the influence of different moment magnitude pools on magnitude homogenization regressions was presented. The control moment magnitude pool is composed of earthquake records from GCMT.
Ausatha Rabbanny Yanto, Eric Yee
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The role of short-term memory and visuo-spatial skills in numerical magnitude processing: Evidence from Turner syndrome. [PDF]
PLoS ONE, 2017 Most studies on magnitude representation have focused on the visual modality with no possibility of disentangling the influence of visuo-spatial skills and short-term memory (STM) abilities on quantification processes.
Lucie Attout +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Developmental Continuity in the Link Between Sensitivity to Numerosity and Physical Size
Journal of Numerical Cognition, 2015 Converging evidence suggests that representations of number, space, and other dimensions depend on a general representation of magnitude. However, it is unclear whether there exists a privileged relation between certain magnitude dimensions or if all ...
Ariel Starr, Elizabeth M. Brannon
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Do We Have a Sense for Irrational Numbers?
Journal of Numerical Cognition, 2017 Number sense requires, at least, an ability to assess magnitude information represented by number symbols. Most educated adults are able to assess magnitude information of rational numbers fairly quickly, including whole numbers and fractions.
Andreas Obersteiner, Veronika Hofreiter
doaj +1 more source
, 2021 This study investigated processing/strategy complexity to activate magnitude representation for common fractions (1/4, 1/3, 1/2, 2/3, and 3/4), and the precision of their magnitude representations on the mental number line. We compared the magnitude comparison performance for pairs involving any one of common fractions and pairs of two uncommon ...
Tanida, Yuki, Okamoto, Masahiko
openaire +1 more source