Results 51 to 60 of about 5,473 (218)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

CONSTRUCTION OF RESIDUE NUMBER SYSTEM USING DIAGONAL FUNCTION OF SPECIAL TYPE

Современная наука и инновации, 2022
Residue Number System (RNS) is a non-positional number system, which is a promising tool for increasing performance of digital devices. However, because of RNS is non-positional number system, magnitude comparison of numbers in RNS form is impossible, so
N. F. Semyonova, N. I. Chervyakov, P. A. Lyakhov, M. V. Valueva, G. V. Valuev   +4 more
doaj  

On the neuro-cognitive foundations of basic auditory number processing: an fMRI study

Behavioral and Brain Functions, 2010
Background It is widely agreed that numbers automatically activate a magnitude representation. Nevertheless, so far no systematic evaluation of the neuro-cognitive correlates has been provided for the case of auditorily presented numbers.
Moeller Korbinian, Klein Elise, Nuerk Hans-Christoph, Willmes Klaus   +3 more
doaj   +1 more source

Symbolic Numerical Magnitude Processing Is as Important to Arithmetic as Phonological Awareness Is to Reading. [PDF]

PLoS ONE, 2016
In this article, we tested, using a 1-year longitudinal design, whether symbolic numerical magnitude processing or children's numerical representation of Arabic digits, is as important to arithmetic as phonological awareness is to reading.
Kiran Vanbinst, Daniel Ansari, Pol Ghesquière, Bert De Smedt   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Neural Correlate Differences in Number Sense Between Children With Low and Middle/High Socioeconomic Status

Frontiers in Psychology, 2020
Although some cognitive studies provided reasons that children with low socioeconomic status (SES) showed poor mathematical achievements, there was no explicit evidence to directly explain the root of lagged performance in children with low SES ...
Qing Bao, Qing Bao, Li Jin Zhang, Li Jin Zhang, Li Jin Zhang, Yuan Liang, Yan Bang Zhou, Gui Li Shi   +7 more
doaj   +1 more source

An fMRI study of magnitude comparison and exact addition in children [PDF]

Magnetic Resonance Imaging, 2010
By contrast to the adult literature, in which a consistent parietofrontal network for number processing has been identified, the data from studies of number processing in children have been less consistent, probably due to differences in study design and control conditions.
Ernesta M, Meintjes, Sandra W, Jacobson, Christopher D, Molteno, J Christopher, Gatenby, Christopher, Warton, Christopher J, Cannistraci, John C, Gore, Joseph L, Jacobson   +7 more
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Timed magnitude comparisons of numerical and nonnumerical expressions of uncertainty [PDF]

Memory & Cognition, 1989
Two experiments involving paired comparisons of numerical and nonnumerical expressions of uncertainty are reported. Subjects were timed under two opposing sets of instructions ("choose higher probability" vs. "choose lower probability"). Numerical comparisons were consistently faster and easier than their nonnumerical counterparts.
A, Jaffe-Katz, D V, Budescu, T S, Wallsten   +2 more
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source