Results 231 to 240 of about 304,551 (334)

Thermoresponsive Graft Copolymers of <i>N</i>‑Isopropylacrylamide and Hyperbranched Polyglycerol as Thermally Induced Drug Delivery and Release Nanoformulation Systems for Curcumin with High Colloidal Stability and Enhanced Anticancer Effect. [PDF]

ACS Omega
Kasza G, Fábián Á, Fecske D, Petróczy A, Horváti K, Iván B.   +5 more
europepmc   +1 more source

How Amino Acids Intercalate in CaFe Layered Double Hydroxides: A Combined RIXS and NEXAFS Study

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Intercalation of amino acids in layered double hydroxides offers a road to functional (bio)catalysts. With resonant soft x‐ray spectroscopy we probe the electronic structure of these systems and observe activation and passivation of electronic states as well as bond formation between the amino acid and the LDH upon intercalation.
R. Büchner, A. Born, K. Ruotsalainen, R. Decker, A. Pietzsch   +4 more
wiley   +1 more source

Double Disguise: Camouflaging Photocages for Bioorthogonally Controlled Conditional Activation. [PDF]

J Am Chem Soc
Ember O, Németh K, Kern D, Kormos A, Kele P, Bojtár M.   +5 more
europepmc   +1 more source

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

Triarylpyrylium-based fluorescent DNA-binding dyes - facile synthesis, substituent effects, and sensing mechanism. [PDF]

RSC Adv
Domahidy F, Cseri L, Turczel G, Huszár B, Rózsa BJ, Mucsi Z, Kovács E.   +6 more
europepmc   +1 more source

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

Clinical Pharmacology &Therapeutics, EarlyView.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen, Jeffrey L. Woodhead, Brett A. Howell, Lisl K. M. Shoda, Dolly A. Parasrampuria, Jiayin Huang, Megumi Iwai, Faith D. Ottery, Xuegong Wang, Marci English, Kentaro Miyazaki, Paul B. Watkins   +11 more
wiley   +1 more source

Longitudinal Systolic Excursion of the Mitral Annular Plane and Left Ventricular Rotational Mechanics Are Associated in Healthy Adults-Three-Dimensional Speckle-Tracking Echocardiography-Derived Insights from the MAGYAR-Healthy Study. [PDF]

J Clin Med
Nemes A, Bordács B, Ambrus N, Lengyel C.   +3 more
europepmc   +1 more source

National Identity Meaning and Attitudes Toward War, Peace, and the Future of Ukraine

Conflict Resolution Quarterly, EarlyView.
ABSTRACT The link between attitudes and social identity is complex, influencing perceptions, motivations, and actions. Social psychological research mainly focused on the role of attitude in identity formation, particularly in the contexts of social movements and collective action.
Karina V. Korostelina, Ksenia Bakhtiarova, A. Zakharchenko, O. Rohalov, V. Molotsiian, O. Zakharchenko, M. Fursenko   +6 more
wiley   +1 more source

Threat-related corticocortical connectivity elicited by rapid auditory looms. [PDF]

Sci Rep
Ignatiadis K, Barumerli R, Deco G, Tóth B, Baumgartner R.   +4 more
europepmc   +1 more source

Does Institutional Ownership Structure Reduce Greenhouse Gas Emissions? An In‐Depth Study of Corporations Social Responsibility of European‐Listed Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Motivated by the growing attention and concerns surrounding climate change and the potential role of institutional investors' ownership concentration (OC) in reducing corporations' greenhouse gas (GHG) emissions, this article explores the relationship between various forms of institutional ownership and firms' GHG emission intensity. To do so,
Daniele Giordino, Elisa Ballesio, Aradhana Galgotia, Laura Broccardo   +3 more
wiley   +1 more source