Results 101 to 110 of about 8,547,061 (286)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Research on RV Reducer Shaft Bearing Force and Structural Optimization

Lubricants
This paper addresses the unclear bearing force of an RV reducer shaft by establishing a transmission model and analyzing the force situation of each component.
Xiaoxu Pang, Dingkang Zhu, Xinlong Wang, Minghao Yang, Qiaoshuo Li, Duo Liu, Hai Wu   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Vibration Testing of Main Shaft Bearing for Offshore Direct-Drive Wind Turbine Generator System

南方能源建设
[Objective] Wind turbine generator systems (WTGS) are prone to various failures due to harsh operating environments. As a central component of the transmission system, the main bearing has early failures that are difficult to detect and evaluate ...
Kang XIONG, Yuan LI, Benben MA, Lin WANG, Rong YUAN   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Plain Bearing Test Methods

<div class="section abstract"> <div class="htmlview paragraph">This SAE Aerospace Recommended Practice (ARP) establishes methods for testing airframe plain bearings. The purpose of ARP5448 and its associated slash sheets is to document test
null null, ACBG Plain Bearing Committee
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Plain bearing stresses due to forming and oil film pressure

, 2009
This paper describes a methodology for assessing critical stress ranges arising in automotive plain bearings during engine operations. An industry-produced and run simulation program provides information on oil film pressure and overall bearing ...
Burke-Veliz, A., Merritt, D., Wang, D., Reed, P.A.S., Wahdy, N., Syngellakis, S.   +5 more
core   +2 more sources

ARC-Informer: Axial–Radial Coupling-Aware Informer for Wind Turbine Main Bearing Health Monitoring

Applied Sciences
Wind turbine main bearings are critical drivetrain components whose operating status directly affects the stability and safety of the entire unit. However, traditional unsupervised health monitoring methods suffer from difficulty in capturing early weak ...
Zijing Xie, Xiaocong Xiao, Ziyue Zhang
doaj   +1 more source