Results 81 to 90 of about 8,547,061 (286)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Wind EnergyThis paper studies the rating lives of wind turbine main bearings, as determined by the IEC 61400‐1 and ISO 281 standards. A critical review of relevant bearing life theory and turbine design requirements is provided, including discussion on possible ...
Jarred Kenworthy +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The application of spectral kurtosis on Acoustic Emission and vibrations from a defective bearing [PDF]
, 2011 The application of Acoustic Emission (AE) technology for machine health monitoring is gaining ground as power tool for health diagnostic of rolling element bearing.
Mba, David +7 more
core +1 more source
Selection of the Buoy Main Bearing of CALM Single Point Mooring System
Shiyou jixie, 2018 At present, the study of single point mooring system in China is still in its infancy. There is little research on CALM single point buoy main bearing.
Ma Bangyong
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A Study of Motor Bearing Fault Diagnosis using Modulation Signal Bispectrum Analysis of Motor Current Signals [PDF]
, 2013 Failure of induction motors are a large concern due to its influence over industrial production. Motor current signature analysis (MCSA) is common practice in industry to find motor faults. This paper presents a new approach to detection and diagnosis of
Chen, Zhi +5 more
core +1 more source
Frontiers in Aerospace EngineeringThis paper proposes a method that significantly improves the prediction accuracy of structural degradation in the main bearing wall of diesel engine cylinders.
Weiqing Huang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source