Results 61 to 70 of about 8,547,061 (286)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Regression-based Main Bearing Load Estimation

, 2023
Abstract. The premature failure of wind turbines due to unknown loads leads to a reduction in competitiveness compared to other energy sources. Especially the failure of main bearings results in high costs and downtimes, as for an exchange of this component the rotor needs to be demounted.
Amin Loriemi, Georg Jacobs, Vitali Züch, Timm Jakobs, Dennis Bosse   +4 more
openaire   +2 more sources

Population genetics of the main population of brown bears in southwest Asia [PDF]

PeerJ, 2018
Genetic studies of the Eurasian brown bear (Ursus arctos) have so far focused on populations from Europe and North America, although the largest distribution area of brown bears is in Asia. In this study, we reveal population genetic parameters for the brown bear population inhabiting the Grand Kaçkar Mountains (GKM) in the north east of Turkey ...
Ambarlı, Hüseyin, Mengüllüoğlu, Deniz, Fickel, Jörns, Förster, Daniel W.   +3 more
openaire   +3 more sources

Fatigue Life Prediction of Main Bearings in Wind Turbines Under Random Wind Speeds

Machines
To address the complex operating conditions and challenging dynamic characteristics of bearings in the main shaft transmission system of wind turbines, this study investigates a specific wind turbine model.
Likun Fan, Ziwen Wu, Yiping Yuan, Xiaojun Liu, Wenlei Sun   +4 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A Method for Evaluating the Performance of Main Bearings of TBM Based on Entropy Weight–Grey Correlation Degree

Sensors
The main bearing of a tunnel boring machine (TBM) is a critical component of the main driving system that enables continuous excavation, and its performance is crucial for ensuring the safe operation of the TBM.
Zhihong Sun, Yuanke Wu, Hao Xiao, Panpan Hu, Zhenyong Weng, Shunhai Xu, Wei Sun   +6 more
doaj   +1 more source

Influence of Radial Journal Profile of Main Bearing on Lubrication State

Jixie chuandong, 2021
Taking the main bearing of a diesel engine as the study object， the lubrication state analysis model of the main bearing is established by taking the roughness and elastic deformation of the main bearing surface into account， and the influence of the ...
Chunjian Li, Junsheng Zhao, Guixiang Zhu, Xiuchun Li, Guodong Zhang   +4 more
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Fault diagnosis method of mine hoist main bearing with small sample based on VAE-WGAN

Meitan kexue jishu
As a key component of the hoist, the main bearing may deteriorate in performance and cause faults during long-term high-speed and heavy-duty service.
Fan JIANG, Hongyan SONG, Xi SHEN, Zhencai ZHU, Shuman CHENG   +4 more
doaj   +1 more source