Results 51 to 60 of about 344,259 (263)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analysis of Factors Affecting Lubrication Performance of Crankshaft Main Bearing Considering Thermal Effect

Jixie chuandong, 2022
In view of the factors affecting the lubrication performance of crankshaft main bearing, an elastohydrodynamic lubrication model of crankshaft main bearing, considering thermal effect, is established. The model takes the external load of bearing, bearing
Shao Kang, Wang Guangdong, Bi Fengrong
doaj  

Population genetics of the main population of brown bears in southwest Asia [PDF]

PeerJ, 2018
Genetic studies of the Eurasian brown bear (Ursus arctos) have so far focused on populations from Europe and North America, although the largest distribution area of brown bears is in Asia. In this study, we reveal population genetic parameters for the brown bear population inhabiting the Grand Kaçkar Mountains (GKM) in the north east of Turkey ...
Ambarlı, Hüseyin, Mengüllüoğlu, Deniz, Fickel, Jörns, Förster, Daniel W.   +3 more
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Fatigue Life Prediction of Main Bearings in Wind Turbines Under Random Wind Speeds

Machines
To address the complex operating conditions and challenging dynamic characteristics of bearings in the main shaft transmission system of wind turbines, this study investigates a specific wind turbine model.
Likun Fan, Ziwen Wu, Yiping Yuan, Xiaojun Liu, Wenlei Sun   +4 more
doaj   +1 more source

Main Bearing Behavior of Marine Diesel Engine

JOURNAL OF THE MARINE ENGINEERING SOCIETY IN JAPAN, 2000
Recent large 2-stroke marine diesel engines have been developed for more powerful, longer strokes, lighter mass and in a more compact size. As for main bearings of the engines, the higher degree specifications have been required.For improving the reliability of the bearing, it has been important to grasp the behavior of the bearing as our first study ...
Sugimoto, Iwao, Baba, Shinji, Yatsuo, Masao, Tanaka, Haruo   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Method for Evaluating the Performance of Main Bearings of TBM Based on Entropy Weight–Grey Correlation Degree

Sensors
The main bearing of a tunnel boring machine (TBM) is a critical component of the main driving system that enables continuous excavation, and its performance is crucial for ensuring the safe operation of the TBM.
Zhihong Sun, Yuanke Wu, Hao Xiao, Panpan Hu, Zhenyong Weng, Shunhai Xu, Wei Sun   +6 more
doaj   +1 more source

Influence of Radial Journal Profile of Main Bearing on Lubrication State

Jixie chuandong, 2021
Taking the main bearing of a diesel engine as the study object， the lubrication state analysis model of the main bearing is established by taking the roughness and elastic deformation of the main bearing surface into account， and the influence of the ...
Chunjian Li, Junsheng Zhao, Guixiang Zhu, Xiuchun Li, Guodong Zhang   +4 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source