Results 51 to 60 of about 8,547,061 (286)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Gradual Deterioration Behavior of the Load-Bearing Strength of Main Cable Wires in a Suspension Bridge

open access: yesApplied Sciences, 2022
The main cable is the primary load-bearing component of a long-span multi-tower suspension bridge. The interaction between a dead load, vehicle load, wind load, and the corrosion environment leads the main cable wire to exhibit tribo-corrosion-fatigue ...
Hailang Chong   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Detection and Diagnosis of Rolling Element Bearing Faults Using Time Encoded Signal Processing and Recognition [PDF]

open access: yes
This thesis presents a systematic study of using TESPAR (Time Encoded Signal Processing and Recognition), which presently is in use as an effective tool for speech recognition and shows great advantages in computational demands and accuracy, to develop a
Abdusslam, Shukri Ali
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Acoustic Emissions and monitoring bearing health [PDF]

open access: yes, 2003
Acoustic emission (AE) was originally developed for non-destructive testing of static structures. however, over the years its application has been extended to health monitoring of rotating machines and bearings.
Mba, David
core   +1 more source

Impact Assessment of Dynamic Loading Induced by the Provision of Frequency Containment Reserve on the Main Bearing Lifetime of a Wind Turbine

open access: yesEnergies, 2023
The components of an operational wind turbine are continuously impacted by both static and dynamic loads. Regular inspections and maintenance are required to keep these components healthy.
Narender Singh   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Analysis of Factors Affecting Lubrication Performance of Crankshaft Main Bearing Considering Thermal Effect

open access: yesJixie chuandong, 2022
In view of the factors affecting the lubrication performance of crankshaft main bearing, an elastohydrodynamic lubrication model of crankshaft main bearing, considering thermal effect, is established. The model takes the external load of bearing, bearing
Shao Kang, Wang Guangdong, Bi Fengrong
doaj  

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