Results 71 to 80 of about 8,547,061 (286)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Effect of Main Bearing Surface Profile on Crankshaft Lubrication and Vibration Characteristic
Jixie chuandong, 2022 Taking the main bearing-main journal of a six-cylinder diesel engine as the research object，based on the elastic- -fluid lubrication theory and the micro-bump contact theory and considering factors such as journal misalignment and main bearing surface ...
Guixiang Zhu +5 more
doaj
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Effect of Relative Density and Stress Level on the Bearing Capacity of Footings on Sand [PDF]
, 2010 The design of shallow foundations relies on bearing capacity values calculated using empirical procedures that are based in part on solutions obtained using the method of characteristics, which assumes a soil that is perfectly plastic following an ...
Loukidis, D, Salgado, Rodrigo
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Running performance of an aerodynamic journal bearing with squeeze film effect [PDF]
, 2013 Results of theoretical and experimental studies concerning the performance of an aerodynamic journal bearing which running is assisted by squeeze film ultrasonic levitation (SFUL) are presented in this paper.
Stolarski, TA, Sho, T, Yoshimoto, S
core +1 more source
Reductions in wind farm main bearing rating lives resulting from wake impingement [PDF]
Wind Energy ScienceThis paper studies the impacts of wake impingement on main bearing rating lives predicted during the wind turbine design stage. A computational tool chain was developed to explore and quantify these effects across a wind farm populated by 10 MW wind ...
J. Quick +9 more
doaj +1 more source