Results 121 to 130 of about 7,590,271 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Iwasawa Main Conjecture for Supersingular Elliptic Curves and BSD conjecture

, 2014
The preprint is superseded by part of the new preprint 2409 ...
openaire   +2 more sources

A Note on the Main Conjecture over Q

, 2018
In this note we show how the main conjecture of the Iwasawa theory over Q has a natural place in the context of the Galois representation of the Galois group $Gal(\bar Q/Q)$ on the etale pro-p fundamental group of the projective line minus three points.
Kakde, Mahesh, Wojtkowiak, Zdzislaw
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

New Proof of the Property of Stirling Number Based on Fubini Polynomials

Journal of Mathematics
The main purpose of this article is using the elementary methods and the properties of the Fubini polynomials to study the congruence properties of a signless Stirling number of the first kind and solve a conjecture proposed by J. H. Zhao and Z. Y. Chen.
Li Wang, Xiaoge Liu
doaj   +1 more source

Smoothing, scattering and a conjecture of Fukaya

Forum of Mathematics, Pi
In 2002, Fukaya [19] proposed a remarkable explanation of mirror symmetry detailing the Strominger–Yau–Zaslow (SYZ) conjecture [47] by introducing two correspondences: one between the theory of pseudo-holomorphic curves on a Calabi–Yau manifold ...
Kwokwai Chan, Naichung Conan Leung, Ziming Nikolas Ma   +2 more
doaj   +1 more source

The anticyclotomic main conjectures for elliptic curves

Mathematische Annalen
The goal of this article is to obtain a proof of the Main conjectures of Iwasawa theory for rational elliptic curves over anticyclotomic extensions of imaginary quadratic fields, under mild arithmetic assumptions, both in the case where the rational prime $p$ is good ordinary or supersingular.
Massimo Bertolini, Matteo Longo, Rodolfo Venerucci   +2 more
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source