Results 121 to 130 of about 3,154,545 (339)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Maintainability Allocation of EMUs Electric Traction Systems

机车电传动, 2014
System maintainability allocation method was expounded. Function diagram and mathematical model on maintainability for EMUs electric traction systems were established, and weighted method was used for the distribution.
SHAO Zhi-he, HE-zai, LIU Xue-quan
doaj  

Conversion and fusion method of multi-source and different populations maintainability prior data. [PDF]

Heliyon, 2023
Zhou C, Xu D, Wang Z.
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes

, 2017
Luciéle Guerra Minuzzi, Luís Rama, Nicolette C. Bishop, Fátima Rosado, António Martinho, Artur Paiva, Ana Teixeira   +6 more
openalex   +2 more sources

Body temperature and physical performance responses are not maintained at the time of pitch-entry when typical substitute-specific match-day practices are adopted before simulated soccer match-play

, 2020
Samuel P. Hills, Hendrickus G. J. Aben, David Starr, Liam P. Kilduff, Shawn M. Arent, Martin J. Barwood, Jon N. Radcliffe, Carlton Cooke, Mark Russell   +8 more
openalex   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Maintaining values [PDF]

British Dental Journal, 2007
openaire   +2 more sources

The Acknowledgement of Corporation’s Register Maintained by the Ministry of Law and Human Rights as Authentic Evidence in Court of Law [PDF]

, 2020
Gunawan Widjaja
openalex   +1 more source