Results 121 to 130 of about 6,268,728 (387)

Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

open access: yesCell Reports, 2013
Holliday junctions (HJs), the DNA intermediates of homologous recombination, need to be faithfully processed in order to preserve genome integrity. In human cells, the BLM helicase complex promotes nonnucleolytic dissolution of double HJs.
Elizabeth Garner   +4 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

An approach to software maintenance support using a syntactic source code analyser data base : this thesis is presented in a partial fulfillment of the requirements for the degree of Master of Arts in Computer Science at Massey University [PDF]

open access: yes, 1987
In this thesis, the development of a software maintenance tool called a syntactic source code analyser (SSCA) is summarised. An SSCA supports other maintenance tools which interact with source code by creating a data base of source information which has ...
Parkin, Peter Vivian
core  

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Definition of Maintenance and Maintenance Types with Due Care on Preventive Maintenance

open access: yes, 2023
In this chapter maintenance concept is defined and maintenance types are classified with regard to implementing maintenance policies toward preventive maintenance. Especially achieving planned maintenance policies toward preventive (planned) maintenance and condition based maintenance policies toward predictive maintenance is taken into consideration ...
openaire   +2 more sources

Maintenance factors in building design [PDF]

open access: yes, 2006
The degree to which the design of a building embraces maintenance considerations has a major impact on its performance. In Malaysia for instance, most designers claimed to have knowledge and experience on building maintenance aspects but only few are ...
Aris, Rozita
core  

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

open access: yesFEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos   +3 more
wiley   +1 more source

Maintenance of Automated Test Suites in Industry: An Empirical study on Visual GUI Testing

open access: yes, 2016
Context: Verification and validation (V&V) activities make up 20 to 50 percent of the total development costs of a software system in practice. Test automation is proposed to lower these V&V costs but available research only provides limited empirical ...
Alégroth, Emil   +2 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

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