Results 121 to 130 of about 6,138,855 (383)
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Challenges in predictive maintenance – A review
CIRP - Journal of Manufacturing Science and Technology, 2023 P. Nunes, J. Santos, E. Rocha
semanticscholar +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Development of an Ant Colony Optimization Algorithm to improve Maintenance Process Efficiency [PDF]
, 2010 Efficient maintenance policies are of fundamental importance because of their fallbacks into the safety and economics of air traffic operations. Usually the optimization of maintenance process is limited to a resource optimization in position and number.
D'AMATO, EGIDIO +2 more
core
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Vedolizumab as induction and maintenance therapy for Crohn's disease.
New England Journal of Medicine, 2013 BACKGROUND The efficacy of vedolizumab, an α4β7 integrin antibody, in Crohn's disease is unknown. METHODS In an integrated study with separate induction and maintenance trials, we assessed intravenous vedolizumab therapy (300 mg) in adults with active ...
W. Sandborn +16 more
semanticscholar +1 more source
Thruster maintenance system Patent [PDF]
, 1971 System for removing and repairing spacecraft control thrusters by use of portable air ...
Hethcoat, J. P., Norton, R. H.
core +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Management of Maintenance on an e-Maintenance Platform
, 2017 Maintenance of assets is an important part of the asset life cycle. Emergence ofe-technologies has enabled faster and efficient maintenance activities withe-maintenance. This paper presents a maintenance management model on ane-maintenance platform, which uses Return on Investment (RoI) as the criteria for decision-making.
Jantunen, Erkki +4 more
openaire +2 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source