Results 81 to 90 of about 2,882,352 (249)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2008 proven difficult in the absence of design information [19]; maintainers often spend considerable energy trying to recover this design information before making changes [15].
Lditional Maintenance Has
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Journal of Engineering and Applied ScienceThe precise forecasting of the Remaining Useful Life (RUL, expressed in hours) of aircraft engine-like systems using a synthetic dataset designed to mimic real engine degradation patterns is a key factor in setting up maintenance schedules that are cost ...
Yankai Bi, Chao Wang, Yuan Chi
doaj +1 more source
ElectricaTo address issues such as inadequate fault tolerance, long computation time, and limited universality in fault location for active distribution networks, this paper proposes a fault location method that combines Petri nets with an improved particle swarm
Yunfeng Xia +4 more
doaj +1 more source
Fatigue performance analysis of dental implants: Influence of thread design [PDF]
MATEC Web of ConferencesThis study investigates the fatigue performance of dental implants made from titanium alloy (Ti-6Al-4V), with a focus on the influence of thread geometry on fatigue resistance.
Elouirdini Hanane +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Reliability Analysis of Switches and Crossings – A Case Study in Swedish Railway [PDF]
International Journal of Railway Research, 2017 It is reported that switches and crossings (S&C) are one of the subsystems that cause the most delays on Swedish Railways while accounting for at least 13% of maintenance costs.
Behzad Ghodrati +2 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source