Results 101 to 110 of about 1,371,472 (303)

A novel refined maintenance strategy for full life cycle of high‐speed automatic train protection system

IET Intelligent Transport Systems
Automatic train protection (ATP) system is essential for ensuring the safe operation of high‐speed trains. However, the existing extensive and fixed maintenance mode of the ATP system results in a waste of resources.
Renwei Kang, Yanzhi Pang, Jianfeng Cheng, Peng Xu, Jianqiu Chen, Kaiyuan Zhang   +5 more
doaj   +1 more source

Software maintenance in scientific and engineering environments: An introduction and guide [PDF]

The purpose of software maintenance techniques is addressed. The aims of perfective, adaptive and corrective software maintenance are defined and discussed, especially in the NASA research environment. Areas requiring maintenance, and tools available for
Wright, David
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Current Status and Future Prospects of Digital Twin Technology Applications in Intelligent Transportation Infrastructure Management

IET Intelligent Transport Systems
Digital twin technology has emerged as a promising solution for the digital transformation of transportation infrastructure. This paper presents a comprehensive review of digital twin technology in the transportation industry, analyzing its relationship ...
Chao Gao, Lei Jia, Maopeng Sun, Junshao Luo   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Numerical investigation of aerodynamic performance in a morphing wing with flexible leading edge using computational fluid dynamics

Journal of Engineering and Applied Science
In this study, a numerical investigation into the sustained aerodynamic performance of a morphing wing equipped with a flexible leading edge, employing a 2-dimensional NACA0012 airfoil configuration, is conducted.
Junjie Shi, Fei Han, Taorui Li, Chao Liu
doaj   +1 more source

Bioengineering Techniques for Soil Erosion Protection and Slope Stabilization [PDF]

The use of bio-engineering methods for soil erosion protection and slope stabilization has a long tradition. Old methods with rocks and plants, structures of timber have been used over the past centuries.
Ioannis Stathakopoulos, Julia Georgi
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Data collection procedures for the Software Engineering Laboratory (SEL) database [PDF]

This document is a guidebook to collecting software engineering data on software development and maintenance efforts, as practiced in the Software Engineering Laboratory (SEL).
Heller, Gerard, Valett, Jon, Wild, Mary
core   +1 more source