Results 91 to 100 of about 660,261 (307)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Retracted: Urban Landscaping Landscape Design and Maintenance Management Method Based on Multisource Big Data Fusion. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessing maintenance management IT on the basis of IT maturity [PDF]

, 2009
Research shows that investments in IT have a positive correlation to company profitability and competitiveness. This is the case also for maintenance management IT (MMIT), i.e.
Kans, Mirka
core   +2 more sources

Dynamic Load Identification on Prefabricated Girder Bridges Based on a CNN and Dynamic Strain Data

Buildings
The vehicle load on a bridge is a critical and dynamic variable. It adversely affects bridges, especially when overloading occurs. Bridges are prone to fatigue damage or collapse.
Lun Zhao, Wenqi Wu, Xuetao Zhang, Liang Li, Pan Guo, Shaolin Yang, Yingchun Cai   +6 more
doaj   +1 more source

MODERN MANAGEMENT METHODS FOR EQUIPMENT MAINTENANCE [PDF]

The concept of maintenance in the field of complex equipment wasdeveloped in the USA being quickly adopted by European countries and Japan. TheAmerican maintenance concept has the significance of creating a support system forindustrial equipment ...
Ciprian Cucu, Ioan Cucu
core  

An investigation into the need and implementation of Total Productive Maintenance (TPM) in Libyan cement industry [PDF]

, 2011
The international competition and the demand to increase productivity of manufacturing and production lines have attracted the management of industrial organisations from a wide spectrum to implement Total Productive Maintenance (TPM) as a tool for ...
Graisa, MM
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Implementation of Business Intelligence for Sales Prediction and Inventory Optimization and Maintenance in SME Carton Box Company with Open-Source Application

Management Systems in Production Engineering
This study aims to implement business intelligence (BI) as a solution to the challenges faced by the carton box manufacturing company in improving operational efficiency and supporting data-based decision-making.
Gozali Lina, Zulfan Pricilia Micca, Sukania I Wayan, Ismail Syuhaida, Cheng Wan Hee, Masrom Maslin, Robin Christhoper   +6 more
doaj   +1 more source

Highly Reliable Multicomponent MEMS Sensor for Predictive Maintenance Management of Rolling Bearings. [PDF]

Micromachines (Basel), 2023
Landi E, Prato A, Fort A, Mugnaini M, Vignoli V, Facello A, Mazzoleni F, Murgia M, Schiavi A.   +8 more
europepmc   +1 more source