Results 81 to 90 of about 11,632,566 (350)

Dynamic Maintenance Cost Optimization in Data Centers: An Availability-Based Approach for K-out-of-N Systems

Buildings
Data Centers (DCs) are critical infrastructures that support the digital world, requiring fast and reliable information transmission for sustainability.
Mostafa Fadaeefath Abadi, Mohammad Javad Bordbari, Fariborz Haghighat, Fuzhan Nasiri   +3 more
doaj   +1 more source

OMCTA: A novel knowledge-based technique to evaluate the influence of O&M actions on maintenance management

International Journal of Industrial Engineering and Management, 2020
Human error is a major cause of unavailability of industrial equipment. Consequently, several approaches attempt to assess how this issue influences maintenance management.
C.A. Murad, A.H.A. Melani, M.A.C. Michalski, A.C. Netto, G.F.M. Souza, S.I. Nabeta   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Review of Pavement Condition Evaluation Index Systems in China and Abroad

Zhongwai Gonglu
With the increasingly complex operating conditions of roads, it has become a consensus among countries to improve the accuracy and systematicness of maintenance decisions.
CHEN Leilei, YANG-LI Wenyun, LI Wei, Muhammad Thlha, QIAN Zhendong   +4 more
doaj   +1 more source

Integrated reliability centred maintenance approach in public sector facilities management. [PDF]

, 2014
Reliability Centred Maintenance (RCM) is focused on ensuring an asset continues to provide its designed function in its present operating context. Through a number of stages, RCM allows for thorough and constant monitoring of assets to maintain their ...
Bralee, Steve, Marasini, Ramesh
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

VLED and formula LED in the management of type 2 diabetes: defining the clinical need and research requirements [PDF]

, 2011
It has been known for many years that substantial weight loss, achieved by bariatric surgery or non-surgical means can mean normalise glucose tolerance.
Lean, M.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Role of Maintenance and Facility Management in Logistics: A Literature Review [PDF]

, 2014
Purpose - The purpose of this paper is to provide a literature review on the different ways of carrying out Facility Management and related topics in order to uncover that there is limited research regarding the impact of Facility Management on the ...
De Marco, Alberto, Mangano, Giulio
core   +1 more source