Results 61 to 70 of about 660,261 (307)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Optimal Maintenance Management of Offshore Wind Farms

Energies, 2016
Nowadays offshore wind energy is the renewable energy source with the highest growth. Offshore wind farms are composed of large and complex wind turbines, requiring a high level of reliability, availability, maintainability and safety (RAMS).
Alberto Pliego Marugán, Fausto Pedro García Márquez, Jesús María Pinar Pérez   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Methodology for the Calculation of Typical Gas Concentration Values and Sampling Intervals in the Power Transformers of a Distribution System Operator

Energies, 2020
Predictive maintenance strategies in power transformers aim to assess the risk through the calculation and monitoring of the health index of the power transformers.
Sergio Bustamante, Mario Manana, Alberto Arroyo, Raquel Martinez, Alberto Laso   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Bridge Maintenance, Safety, Management, Digitalization and Sustainability [PDF]

Bridge Maintenance, Safety, Management, Digitalization and Sustainability collects the lectures and technical papers presented at the 12th International Conference on Bridge Maintenance, Safety and Management (IABMAS 2024, Copenhagen, Denmark, 24-28 June

core   +3 more sources

Influence of the maintenance management with a comprehensive approach on the efficient and rational operation of vehicle fleets [PDF]

Tehnika, 2017
Companies with own vehicle fleet for freight transport try to carry out the requested transport volume, with lowest possible transportation and maintenance costs.
Vujanović Davor B.
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development of a relationship management framework and related performance matrics for outsourced aircraft maintenance [PDF]

, 2008
Driven by an intensely competitive world, the use of outsourcing is extensive and growing especially in the service business area. Outsourcing provides companies with benefits such as cost reduction and performance enhancement.
Sakburanapech, Araya
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source