Results 41 to 50 of about 561,917 (307)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Maintenance optimization for rolling bearing based on delay time model

International Journal for Simulation and Multidisciplinary Design Optimization
Rolling bearings are critical components in rotating machinery, directly influencing system reliability and performance. Bearing failures, driven by stochastic degradation processes, necessitate accurate reliability assessment and maintenance ...
Bui Minh-Hien, Dang Phuoc-Vinh, Dinh Duc-Hanh, Le-Huu Bao-Thuan, Nguyen Ho-Si-Hung   +4 more
doaj   +1 more source

Development of an Ant Colony Optimization Algorithm to improve Maintenance Process Efficiency [PDF]

, 2010
Efficient maintenance policies are of fundamental importance because of their fallbacks into the safety and economics of air traffic operations. Usually the optimization of maintenance process is limited to a resource optimization in position and number.
D'AMATO, EGIDIO, DUCA, GABRIELLA, G. Del Core   +2 more
core  

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

A model based on cost minimization and reliability enhancement to solve the power plant preventive maintenance scheduling problem [PDF]

, 2015
1. Introduction and problem description The Power Plant Preventive Maintenance Scheduling Problem (PPPMSP) requires determining the period for which generating units of an electric power system should be taken offline for planned preventive ...
Perez-Canto, Salvador
core  

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Schedule Maintenance Task Interval Optimization Method Based on In-service Data

Hangkong gongcheng jinzhan, 2020
Schedule maintenance task interval is a key index representing the reliability and economy of aircraft, and the accumulation of maintenance and fault data after aircraft service provides the basis for the adjustment of maintenance task interval.
LIN Cong, JIANG Qingxi, ZHOU Yang
doaj   +1 more source

Life-cycle of fatigue sensitive structures under uncertainty [PDF]

, 2013
Fatigue is the one of the main contributors to problems related to structural safety of civil and marine structures. Life-cycle management (LCM) techniques considering various uncertainties can be used to predict the safe service life of fatigue ...
Frangopol, Dan M., Soliman, Mohamed
core  

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Assessment of Hull and Propeller Degradation Due to Biofouling Using Tree-Based Models

Applied Sciences
A hull and propeller biofouling assessment framework is presented and demonstrated using a bulk carrier as a case study corresponding to an operational period of two and a half years.
Nikos Themelis, George Nikolaidis, Vasilios Zagkas   +2 more
doaj   +1 more source