Results 41 to 50 of about 149,672 (219)

Impact-Based Maintenance Efficiency Modeling for Multi-Component Systems With Condition-Based Component Selection

IEEE Access
This paper develops an impact-based maintenance efficiency model that dynamically links maintenance effectiveness to the number and criticality of replacement components in multi-component repairable systems. Unlike existing approaches that assume static
Lamia May, Mohamed Arezki Mellal, Sameer Al-Dahidi, Michael Pecht, Youcef Khelfaoui   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Upgrading of a uniform system of technical material means maintenance in the ground forces

Vojnotehnički Glasnik, 2000
Under the conditions of technological modernization and constant development of material means, the macrosystem of maintenance of technical material means in the Ground Forces becomes more and more complex. Complexity of technical support in general, and
Branko Đedović
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessment of Hull and Propeller Degradation Due to Biofouling Using Tree-Based Models

Applied Sciences
A hull and propeller biofouling assessment framework is presented and demonstrated using a bulk carrier as a case study corresponding to an operational period of two and a half years.
Nikos Themelis, George Nikolaidis, Vasilios Zagkas   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

DoE Optimization of Applied Pressure and Mold Size in Manufacturing Homogeneous Alumina Samples by SPS Process under 1000A Current [PDF]

Journal of Applied and Computational Mechanics
Spark plasma sintering (SPS) presents advantages over conventional sintering methods, notably high heating rates and reduced residence times. However, SPS suffers from uneven temperature and stress distributions due to suboptimal sintering parameters ...
Abdelmalek Kriba, Farid Mechighel, Ridha Djebali, Ali Chamkha   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source