Results 61 to 70 of about 2,997,605 (289)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Upgrading of a uniform system of technical material means maintenance in the ground forces

Vojnotehnički Glasnik, 2000
Under the conditions of technological modernization and constant development of material means, the macrosystem of maintenance of technical material means in the Ground Forces becomes more and more complex. Complexity of technical support in general, and
Branko Đedović
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Assessment of Hull and Propeller Degradation Due to Biofouling Using Tree-Based Models

Applied Sciences
A hull and propeller biofouling assessment framework is presented and demonstrated using a bulk carrier as a case study corresponding to an operational period of two and a half years.
Nikos Themelis, George Nikolaidis, Vasilios Zagkas   +2 more
doaj   +1 more source

Maintenance parameters based production policies optimization

, 2012
Purpose - Planning of manufacturing and maintenance activities together, creating a balance between maintenance and production parameters and developments on maintenance will prevent technical and economic losses and increase production efficiency ...
Ozdogan A., Uzun A.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

DoE Optimization of Applied Pressure and Mold Size in Manufacturing Homogeneous Alumina Samples by SPS Process under 1000A Current [PDF]

Journal of Applied and Computational Mechanics
Spark plasma sintering (SPS) presents advantages over conventional sintering methods, notably high heating rates and reduced residence times. However, SPS suffers from uneven temperature and stress distributions due to suboptimal sintering parameters ...
Abdelmalek Kriba, Farid Mechighel, Ridha Djebali, Ali Chamkha   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Joint Optimization Strategy of Condition-Based Maintenance and Spare Parts Ordering for Nonlinear Degraded Equipment under Imperfect Maintenance

, 2022
When existing methods consider the impact of the imperfect maintenance activities on random degraded equipment, they usually assume that the degraded equipment is linear, and set the number of imperfect maintenance activities in advance.
Baokui Yang, Huiqing Li, Xiaosheng Si, Hong Pei, Jianxun Zhang   +4 more
core   +1 more source