Results 81 to 90 of about 156,578 (313)
IEEE AccessThis paper develops an impact-based maintenance efficiency model that dynamically links maintenance effectiveness to the number and criticality of replacement components in multi-component repairable systems. Unlike existing approaches that assume static
Lamia May +4 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Genetic and memetic algorithms for scheduling railway maintenance activities [PDF]
Nowadays railway companies are confronted with high infrastructure maintenance costs. Therefore good strategies are needed to carry out these maintenance activities in a most cost effective way.
Dekker, R., Kaymak, U., Budai-Balke, G.
core +1 more source
A value-centric decision making framework for maintenance services outsourcing [PDF]
, 2011 The shift in mindset of decision makers, from maintenance being a “necessary evil” and “cost centre” to a “profit contributor” in manufacturing companies has driven outsourced maintenance suppliers to employ value-centric approaches in order to design
Toossi, Amir
core
Maintenance, Modeling and Optimization [PDF]
, 2000 List of Figures. List of Tables. Preface. Contributing Authors. Part I: Introduction. 1. Maintenance Modeling Areas M. Ben-Daya, S.O. Duffuaa. Part II: Maintenance Planning & Scheduling. 2. Mathematical Models in Maintenance Planning and Scheduling S.O. Duffuaa. 3. Electric Generator Maintenance Scheduling I. El-Amin. 4.
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Joint optimization of capacity, production and maintenance planning of leased machines [PDF]
, 2020 International audienceThis paper deals with capacity design, production and preventive maintenance planning of a production system made of parallel leased machines. The production system must satisfy a random demand over a finite number of periods.
Hajej, Zied, Rezg, Nidhal, Askri, Tarek
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source