Results 81 to 90 of about 2,997,605 (289)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Vojnotehnički Glasnik, 1999 This work presents a possibility to find the optimum solution in the maintenance of high pressure pump systems when the criteria functions are maximal availability and minimal cost maintenance.
Ljubiša Brkić , Božidar V. Krstić
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Journal of Marine Science and EngineeringThis study addresses the growing need for predictive maintenance in the maritime industry by proposing an optimized strategy for ship engine maintenance.
Damir Budimir +3 more
doaj +1 more source
Maintenance, Modeling and Optimization [PDF]
, 2000 List of Figures. List of Tables. Preface. Contributing Authors. Part I: Introduction. 1. Maintenance Modeling Areas M. Ben-Daya, S.O. Duffuaa. Part II: Maintenance Planning & Scheduling. 2. Mathematical Models in Maintenance Planning and Scheduling S.O. Duffuaa. 3. Electric Generator Maintenance Scheduling I. El-Amin. 4.
openaire +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Understanding the effects of different levels of product monitoring on maintenance operations: A simulation approach [PDF]
, 2013 The move towards integrating products and services has increased significantly. As a result, some business models, such as Product Service Systems (PSS) have been developed.
Alabdulkarim, Abdullah A.
core +3 more sources
Prediction of Expected Fouling Time During Transmembrane Transition in Reverse Osmosis Systems
MembranesMembrane filtration, including reverse osmosis filtration, is widely applied in water treatment worldwide, offering solutions to a broad range of separation challenges.
Jozsef Lakner, Gabor Lakner
doaj +1 more source
Genetic and memetic algorithms for scheduling railway maintenance activities [PDF]
Nowadays railway companies are confronted with high infrastructure maintenance costs. Therefore good strategies are needed to carry out these maintenance activities in a most cost effective way.
Dekker, R., Kaymak, U., Budai-Balke, G.
core