Results 101 to 110 of about 156,578 (313)

Overview of equipment maintenance support mission planning model and solution [PDF]

open access: yesZhihui kongzhi yu fangzhen
Our military’s exploration of equipment support mission planning is still in its infancy, traditional methods are difficult to meet the current equipment support needs, and there is an urgent need to combine with intelligent algorithms, machine learning ...
YANG Liangliang, ZHAO Deyong, LIU Xiaoyong, LIU Jie, SHEN Zixuan
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Mission Reliability-Oriented Selective Maintenance Optimization for Intelligent Multistate Manufacturing Systems With Uncertain Maintenance Quality

open access: yesIEEE Access, 2019
Selective maintenance is widely used as a reliability-centered maintenance strategy due to the limited maintenance resources. However, existing selective maintenance studies only consider basic reliability, which cannot systematically describe the ...
Zhaoxiang Chen   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Is Semantic Query Optimization Worthwhile? [PDF]

open access: yes, 2007
The term quote semantic query optimization quote (SQO) denotes a methodology whereby queries against databases are optimized using semantic information about the database objects being queried.
Genet, Bryan Howard
core  

A Joint Production and Maintenance Optimization of Closed-Loop Production System under Carbon Emission with a Switching Subcontractor Consideration [PDF]

open access: yes, 2019
This study outlines a new forecasting problem of closed-loop production system under environmental aspect by proposing a new solution based on subcontracting.
Hajej, Zied   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Modeling and solving the periodic maintenance problem. [PDF]

open access: yes
We study the problem of scheduling maintenance services. Given is a set of m machines and integral cost-coefficients a(i) and b(i) for each machine i (1Branch-and-price; Column generation; Costs; Linear programming; Model; Models; Optimal; Scheduling ...
Grigoriev, A   +2 more
core  

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