Results 91 to 100 of about 2,997,605 (289)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
IEEE Access, 2019 Selective maintenance is widely used as a reliability-centered maintenance strategy due to the limited maintenance resources. However, existing selective maintenance studies only consider basic reliability, which cannot systematically describe the ...
Zhaoxiang Chen +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
OPSIUnexpected equipment failures in electronics manufacturing can disrupt production continuity, increase maintenance costs, and reduce system reliability. Although reliability-centered maintenance approaches have been widely applied, most studies focus on ...
Muhammad Ridwan Andi Purnomo +1 more
doaj +1 more source
Overview of equipment maintenance support mission planning model and solution [PDF]
Zhihui kongzhi yu fangzhenOur military’s exploration of equipment support mission planning is still in its infancy, traditional methods are difficult to meet the current equipment support needs, and there is an urgent need to combine with intelligent algorithms, machine learning ...
YANG Liangliang, ZHAO Deyong, LIU Xiaoyong, LIU Jie, SHEN Zixuan
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Jointly Production and Correlated Maintenance Optimization for Parallel Leased Machines
, 2017 This paper deals with a preventive maintenance strategy optimization correlated to production for a manufacturing system made by several parallel machines under lease contract. In order to minimize the total cost of production and maintenance by reducing
Nidhal REZG +5 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Optimal maintenance of multi-component systems: a review [PDF]
In this article we give an overview of the literature on multi-component maintenance optimization. We focus on work appearing since the 1991 survey "A survey of maintenance models for multi-unit systems" by Cho and Parlar.
Dekker, R., Nicolai, R.P.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source