Results 101 to 110 of about 2,626,327 (351)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modelling vessel fleet composition for maintenance operations at offshore wind farms [PDF]

, 2018
Chartering a vessel fleet to support maintenance operations at offshore wind farms (OWF's) constitutes one of the major costs of maintaining this type of installations.
García-Fernández, Inmaculada, Gutiérrez-Alcoba, Alejandro, Hendrix, Eligius Maria Theodorus, Ortega López, Gloria   +3 more
core  

A review of key planning and scheduling in the rail industry in Europe and UK [PDF]

, 2015
Planning and scheduling activities within the rail industry have benefited from developments in computer-based simulation and modelling techniques over the last 25 years. Increasingly, the use of computational intelligence in such tasks is featuring more
Blacktop, K., Starr, Andrew G., Tiwari, Ashutosh, Turner, Christopher   +3 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Modeling and solving the periodic maintenance problem. [PDF]

We study the problem of scheduling maintenance services. Given is a set of m machines and integral cost-coefficients a(i) and b(i) for each machine i (1Branch-and-price; Column generation; Costs; Linear programming; Model; Models; Optimal; Scheduling ...
Grigoriev, A, Spieksma, Frederik, Van De Klundert, J   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Optimal Hydropower Maintenance Scheduling in Liberalized Markets

IEEE Transactions on Power Systems, 2018
Maintenance scheduling is an important and complex task in hydropower systems. In a liberalized market, the generation company will schedule maintenance periods to maximize the expected profit.
A. Helseth, Marte Fodstad, B. Mo
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Modelling maintenance scheduling strategies for highway networks. [PDF]

PLoS One, 2022
Tong B, Wang J, Wang X, Zhou F, Mao X, Duan Y.   +5 more
europepmc   +1 more source