Results 131 to 140 of about 2,626,327 (351)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

GNN-DRL Optimization Scheduling Method for Damaged Equipment Maintenance Tasks

Applied Sciences
Aiming at the problems that traditional heuristic algorithms struggle to capture the complex correlations between damaged equipment and dynamically adjust maintenance task requirements in different task scenarios, the Graph Neural Network (GNN) and Deep ...
Mingjie Jiang, Tiejun Jiang, Lijun Guo, Shaohua Liu   +3 more
doaj   +1 more source

A Mathematical Model for HVLV Systems Scheduling and Optimization With Periodic Preventive Maintenance Using (max, +) Algebra [PDF]

, 2012
International audienceThe High-Variety, Low-Volume (HVLV) scheduling problem is one of the most arduous combinatorial optimization problems. This paper considers an interesting formulation of the HVLV scheduling problem using (max, +) algebra while ...
Boukezzoula, Reda, Habchi, Georges, Nasri, Imed   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modelling a Maintenance Scheduling Problem with Alternative Resources [PDF]

, 2010
Effective management of maintenance in buildings can have a signi cant impact on the total life cycle costs and on the building energy use. Nevertheless, the building maintenance scheduling problem has been infrequently studied. In this paper, we present
Badr, Aliaa M., Brown, Kenneth M., Malapert, Arnaud   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Opportunity-Maintenance-Based Scheduling Optimization for Ship-Loading Operation Systems in Coal Export Terminals

Journal of Marine Science and Engineering
As important nodes of the global coal supply chain, coal export terminals bear the tasks of coal storage, processing, and handling, whose efficiency and stability are of great importance with the growing coal shipping market in recent years.
Qi Tian, Yun Peng, Xinglu Xu, Wenyuan Wang   +3 more
doaj   +1 more source

An autonomous system for maintenance scheduling data-rich complex infrastructure: Fusing the railways' condition, planning and cost

, 2018
National railways are typically large and complex systems. Their network infrastructure usually includes extended track sections, bridges, stations and other supporting assets.
I. Durazo-Cardenas, A. Starr, C. Turner, A. Tiwari, L. Kirkwood, M. Bevilacqua, A. Tsourdos, E. Shehab, P. Baguley, Yuchun Xu, C. Emmanouilidis   +10 more
semanticscholar   +1 more source