Results 21 to 30 of about 1,549,556 (233)

Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin

open access: yesActa Crystallographica Section D, Volume 79, Issue 9, Page 830-836, September 2023., 2023
Insight into biosynthetic pathways in the human microbiome can provide details of host–microbe interactions and beneficial symbiosis. In this report, the structure and function of a key bond‐forming enzyme in the biosynthesis of the human genotoxin colibactin is presented.Colibactin is a genotoxic natural product produced by select commensal bacteria ...
Prabhanshu Tripathi   +3 more
wiley   +1 more source

The boundary problem: Defining and delineating the community in field trials with gene drive organisms

open access: yesBioethics, Volume 37, Issue 6, Page 600-609, July 2023., 2023
Abstract Despite widespread and worldwide efforts to eradicate vector‐borne diseases such as malaria, these diseases continue to have an enormous negative impact on public health. For this reason, scientists are working on novel control strategies, such as gene drive technologies (GDTs).
Nienke de Graeff   +4 more
wiley   +1 more source

Healthcare seeking outside healthcare facilities and antibiotic dispensing patterns in rural Burkina Faso: A mixed methods study

open access: yesTropical Medicine &International Health, Volume 28, Issue 5, Page 391-400, May 2023., 2023
Abstract Objective Optimising antibiotic use is important to limit increasing antibiotic resistance. In rural Burkina Faso, over‐the‐counter dispensing of antibiotics in community pharmacies and non‐licensed medicine retail outlets facilitates self‐medication. We investigated its extent, reasons and dispensing patterns.
Daniel Valia   +14 more
wiley   +1 more source

Investigation on Fluid Flow Heat Transfer and Frictional Properties of Al2O3 Nanofluids Used in Shell and Tube Heat Exchanger

open access: yesInternational Journal of Photoenergy, Volume 2023, Issue 1, 2023., 2023
Nanofluids are generally utilized in providing cooling, lubrication phenomenon, and controlling the thermophysical properties of the working fluid. In this paper, nanoparticles of Al2O3 are added to the base fluid, which flows through the counterflow arrangement in a turbulent flow condition.
Debabrata Barik   +5 more
wiley   +1 more source

Cost‐Effectiveness of Arthroscopic Partial Meniscectomy and Physical Therapy for Degenerative Meniscal Tear

open access: yesACR Open Rheumatology, Volume 4, Issue 10, Page 853-862, October 2022., 2022
Objective We examined the cost‐effectiveness of treatment strategies for concomitant meniscal tear and knee osteoarthritis (OA) involving arthroscopic partial meniscectomy surgery and physical therapy (PT). Methods We used the Osteoarthritis Policy Model, a validated Monte Carlo microsimulation, to compare three strategies, 1) PT‐only, 2) immediate ...
Emma E. Williams   +10 more
wiley   +1 more source

Lost in the wind: An integrated approach for the recognition of mixed clastic–carbonate continental aeolianites

open access: yesSedimentology, Volume 69, Issue 5, Page 2203-2227, August 2022., 2022
Abstract Aeolianites with a mixed clastic and carbonate detrital mineralogy are typical deposits of tropical coastal desert environments. These deposits are genetically related to transgressive–regressive cycles, with the shallow‐marine carbonate detrital component being deflated from the exposed seafloor during episodes of glacial sea‐level lowstands,
Francesco Arboit   +5 more
wiley   +1 more source

Scientific realism and underdetermination in quantum theory

open access: yesPhilosophy Compass, Volume 16, Issue 11, November 2021., 2021
Abstract This paper surveys the status of scientific realism in relation to quantum physics, focusing on the problem of underdetermination.
Matthias Egg, Juha Saatsi
wiley   +1 more source

Isolation, not locality

open access: yesPhilosophy and Phenomenological Research, Volume 103, Issue 3, Page 607-619, November 2021., 2021
Abstract There is a long tradition of preferring local theories to ones that posit lawful or causal influence at a spacetime distance. In this paper, we argue against this preference. We argue that nonlocality is scientifically unobjectionable and that nonlocal theories can be known.
Heather Demarest, Michael Townsen Hicks
wiley   +1 more source

Trabalho, classe trabalhadora e proletariado ensaio sobre as contradições e crises do capitalismo contemporâneo

open access: yesRevista Histedbr On-line, 2012
Este artigo discute de forma concisa conceitos chaves do modo de produção capitalista, apartir de O Capital de Karl Marx. Parte-se da premissa que há em O Capital uma unidadelógica, senão dialética, para compreender suas categorias, conceitos e suas ...
Adrián Sotelo Valencia
doaj   +1 more source

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