Results 21 to 30 of about 44,748 (260)

Standardizing Benchmarks for Plant Genomic Prediction

Agronomy
Genomic prediction (GP) is now widely used in crop improvement, but the rapid expansion of GP methods has outpaced the development of standardized evaluation practices. Reported gains from deep learning and other complex models are difficult to interpret
Min Yan, Wenying Wang, Ying Zhang, Han Guo, Zhen Xue, Xueyang Wang, Jun Yan   +6 more
doaj   +1 more source

MADS-box encoding gene Tunicate1 positively controls maize yield by increasing leaf number above the ear

Nature Communications
The leaves above the ear serve as a major source of carbohydrates for grain filling in maize. However, increasing the number of leaves above the ear to strengthen the source and improve maize yield remains challenging in modern maize breeding.
Yan Li, Jian Wang, Shuyang Zhong, Qiang Huo, Qun Wang, Yunlu Shi, Hangqin Liu, Jiacheng Liu, Yang Song, Xiaojian Fang, Zhongwei Lin   +10 more
doaj   +1 more source

The priority of management factors for reducing the yield gap of summer maize in the north of Huang-Huai-Hai region, China

Journal of Integrative Agriculture, 2021
Understanding yield potential, yield gap and the priority of management factors for reducing the yield gap in current intensive maize production is essential for meeting future food demand with the limited resources.
Yue-e LIU, Yu-xin LI, Tian-fang LÜ, Jin-feng XING, Tian-jun XU, Wan-tao CAI, Yong ZHANG, Jiu-ran ZHAO, Rong-huan WANG   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A high-quality chromosome-scale genome assembly of the wild sorghum (Sorghum virgatum)

Scientific Data
Sorghum virgatum (Sv) is a wild subspecies of sorghum (Sorghum bicolor ssp. Verticilliflorum (L.) Moench). We employed Hi-C sequencing and HiFi technology in this study, successfully assembly a high-quality genome for Sv.
Xiaojian Fang, Leina Zhou, Zhongwei Lin
doaj   +1 more source

Crystal Structural Analysis of Oryza sativa SGT1-TPR Domain

Crystals
SGT1 (the suppressor of the G2 allele of Skp1) functions as an adaptor protein that positively regulates plant defense and developmental processes. It comprises three functional domains: the tetratricopeptide repeat (TPR) domain, Chord SGT1 motif (CS ...
Yongqi Chang, Lifeng Ji, Yiling Qin, Yaqi Yi, Chen Qian, Jie Jiang, Tian Liu, Junfeng Liu, Xin Zhang   +8 more
doaj   +1 more source

Exploring differentially expressed genes associated with fertility instability of S-type cytoplasmic male-sterility in maize by RNA-seq

Journal of Integrative Agriculture, 2017
: The germplasm resources for the S-type male sterility is rich in maize and it is resistant to Bipolaris maydis race T and CI, but the commercial application of S-type cytoplasmic male sterility (CMS-S) in maize hybrid industry is greatly compromised ...
Ai-guo SU, Wei SONG, Zi SHI, Yan-xin ZHAO, Jin-feng XING, Ru-yang ZHANG, Chun-hui LI, Meijie LUO, Ji-dong WANG, Jiu-ran ZHAO   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source