Results 131 to 140 of about 19,306 (297)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

IDENTIFYING APPROPRIATE GERMPLASM FOR PARTICIPATORY BREEDING: AN EXAMPLE FROM THE CENTRAL VALLEYS OF OAXACA, MEXICO [PDF]

Identifying the appropriate germplasm to be improved is a key component of any participatory breeding effort because of its implications for impacts on social welfare and genetic diversity. This paper describes a method developed to select a subset of 17
Aguirre, Alfonso, Aragon, Flavio, Bellon, Mauricio R., Castro, Humberto, Diaz, Jaime, Smale, Melinda, Taba, Suketoshi   +6 more
core   +1 more source

Improving N use and performance of arable crops on organic arable farms using an expert group approach (OF0178) [PDF]

, 2002
This is the final report for Defra project OF0178. Government seeks to support the development of organic farming in the UK, but nitrogen (N) almost always limits productivity on organic farms.
Anon
core  

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Maize in China: Production Systems, Constraints, and Research Priorities [PDF]

Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,
Hu, Ruifa, Meng, Erika C.H., Shi, Xiaohua, Zhang, Shihuang   +3 more
core   +1 more source

Maize-Soybean Strip Intercropping Improved Lodging Resistance and Productivity of Maize

International Journal of Agriculture and Biology, 2020
Xifeng Chen, Ning Sun, Yan Gu, Yaliang Liu, Jianfeng Li, Chunsheng Wu, Zhenmin Wang   +6 more
openaire   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

UAV LiDAR-Based Automated Detection of Maize Lodging in Complex Agroecosystems

Drones
Maize lodging poses a significant challenge to agricultural production, severely constraining yield improvement and mechanized harvesting efficiency.
Yajin Wang, Fengbao Yang, Linna Ji
doaj   +1 more source

ADOPTION OF MAIZE AND WHEAT TECHNOLOGIES IN EASTERN AFRICA: A SYNTHESIS OF THE FINDINGS OF 22 CASE STUDIES [PDF]

This paper synthesizes the findings of 22 micro-level studies on technology adoption carried out by the International Maize and Wheat Improvement Center (CIMMYT) with national agricultural research systems in Ethiopia, Kenya, Tanzania, and Uganda from ...
De Groote, Hugo, Doss, Cheryl R., Mwangi, Wilfred, Verkuijl, Hugo   +3 more
core   +1 more source