Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The growth and yield of maize (Zea mays L.) and soyabeans (Glycine max. (L) Merrill) grown as intercrops : a thesis presented in partial fulfilment of the requirement for the degree of Master of Agricultural Science in Plant Science at Massey University [PDF]
, 1986 The effect of plant population maize (Zea mays L.) cultivar (Pioneer 3901) and AMT and Matara cultivars of soyabeans (Glucine max (L) Merill) grown together in an intercropping system was studied.
Kamarudin, Yusoff
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Genetic variances and relationship among traits of an early maturing maize population under drought-stress and low nitrogen environments [PDF]
, 2017 Article purchasedDrought and low soil nitrogen (low N) are major causes of low grain yield of maize (Zea mays L.) in sub-Saharan Africa (SSA). An early maturing maize population, TZE-Y Pop DT STR, had undergone four cycles of selection for drought ...
A. O. Talabi +40 more
core +3 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Designing crop rotations in organic and low-input agriculture: Evaluation of pre-crop effects [PDF]
, 2007 In this overview, the preceding effects of crop pairs are classified by establishing schematic diagrams for use in crop rotation planning in low external input or organic agricultural systems.
Kolbe, Hartmut
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Yield gains in extra-early maize cultivars of three breeding eras under multiple environments [PDF]
, 2017 Open Access JournalAvailability of extra-early maize cultivars has facilitated the expansion of maize production into savannas of West and Central Africa (WCA).
A. O. Talabi +52 more
core +2 more sources
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Crop biotechnology: prospects and opportunities [PDF]
, 2010 SUMMARYThis paper is a brief review summarizing some of the important areas of activity in crop biotechnology likely to be exploited over the medium term (10–20 years), with an emphasis on agronomic traits.
Dunwell, J. M.
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source