Results 51 to 60 of about 72,931 (264)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of maize plant type and row width in ginger/maize intercropping system on yield, economy, and interspecific competition

Frontiers in Plant Science
Ginger/maize intercropping system improves land use efficiency and sustainable agriculture. Field experiments (with sole-cropped ginger (SG) and sole-cropped maize (SM) as controls) tested two maize plant types (flat and compact) and three row widths (2,
Ailin Tian, Linyu Liu, Haodan Zhang, Rui He, Junlan Liu, Guoqing Sun, Qin Huang, Sida Long, Bingxia Yang, Xu Yan, Meixia Zhang, Yun Ren, Qiang Li   +12 more
doaj   +1 more source

Regulator Network Analysis of Rice and Maize Yield-Related Genes

Frontiers in Cell and Developmental Biology, 2020
Rice and maize are the principal food crop species worldwide. The mechanism of gene regulation for the yield of rice and maize is still the research focus at present. Seed size, weight and shape are important traits of crop yield in rice and maize.
Zheng Chen, Zheng Chen, Zijie Shen, Lei Xu, Da Zhao, Da Zhao, Quan Zou   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Mathematical model analysis for maize yield under co-infection of maize streak virus and maize stripe virus diseases with control measures

Journal of Nigerian Society of Physical Sciences
Maize is a staple food for billions of human globally. It is a very important food crop for sustaining global food security, livelihoods, and economic development.
Obiora Collins
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intercropping maize (Zea mays L.) and field beans (Vicia faba L.) for forage, increases protein production

Scientific Reports
In 2005–2007, a field study was conducted into intercropping of maize with faba bean at Pawlowice research station, Wroclaw University of Environmental and Life Sciences.
Józef Sowiński
doaj   +1 more source

Maize-Pigeonpea Intercropping Outperforms Monocultures Under Drought

Frontiers in Sustainable Food Systems, 2020
There is an urgent need to develop resilient agroecosystems capable of helping smallholder farmers adapt to climate change, particularly drought. In East Africa, diversification of maize-based cropping systems by intercropping with grain and tree legumes
Leah L. R. Renwick, Anthony A. Kimaro, Johannes M. Hafner, Todd S. Rosenstock, Amélie C. M. Gaudin   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source