Results 121 to 130 of about 8,230,812 (271)

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Blood Hemoglobin Concentrations and the Incidence of Lower Extremity Peripheral Arterial Disease in Patients Undergoing Hemodialysis: 10‐Year Outcomes of the Q‐Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lower extremity peripheral arterial disease is a potentially lethal cardiovascular complication in patients undergoing hemodialysis. Anemia is a risk factor for cardiovascular disease among the hemodialysis population.
Chiaki Kohara, Shunsuke Yamada, Shigeru Tanaka, Hiroto Hiyamuta, Hiromasa Kitamura, Hokuto Arase, Sho Shimamoto, Masatomo Taniguchi, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano   +10 more
doaj   +1 more source

Discrimination of model in predicting major adverse cardiovascular events (MACE).

, 2015
NRI, Net Reclassification Improvement; IDI, Integrated Discrimination ImprovementDiscrimination of model in predicting major adverse cardiovascular events (MACE).
Jiaojiao Xu (813939), Dongyu Xia (813940), Yu Xiang (261980), Lan Mi (813938), Na Zhao (112953), Zhongwei Liu (723226), Yong Zhang (5893), Zuyi Yuan (143452), Gongchang Guan (813941), Shuo Pan (583102), Xiaojun Liu (58952), Junkui Wang (813942)   +11 more
core   +1 more source

Long-Term Adverse Limb Events After Femoral Artery Endovascular Revascularization: The Boston FAROUT Study

Journal of the Society for Cardiovascular Angiography & Interventions
Background: : Patient, lesion, and procedural characteristics may impact the long-term risks of adverse limb outcomes differently after successful endovascular revascularization for lower extremity peripheral artery disease.
Edwin Mandieka, MD, Ramael Ohiomoba, MD, MPH, Piotr Sobieszczyk, MD, Andrew C. Eisenhauer, MD, Thomas Todoran, MD, Scott Kinlay, MBBS, PhD   +5 more
doaj   +1 more source

Reply to. "inadequate anticoagulation by vitamin K antagonists and major adverse cardiovascular events other than stroke"

, 2016
Comment on Inadequate anticoagulation by Vitamin K Antagonists is associated with Major Adverse Cardiovascular Events in patients with atrial fibrillation. [Int J Cardiol.
PASTORI, DANIELE, PIGNATELLI, Pasquale, BARILLA', Francesco, Lip, Gregory Y. H, VICARIO, TOMMASA, SALIOLA, Mirella, VIOLI, Francesco, CARNEVALE, Roberto, CANGEMI, ROBERTO   +8 more
core   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Localizing value of ecstatic phenomenon in epilepsy surgery: A systematic review

Epileptic Disorders, EarlyView.
Abstract Objective A systematic review was conducted to synthesize current anatomo‐clinical correlations of ecstatic symptoms in focal epilepsy, aiming to provide evidence‐based guidance for interpreting this ictal semiology during presurgical evaluation.
Mihai Dragos Maliia, Fabrice Bartolomei, Fabienne Picard   +2 more
wiley   +1 more source

Programming of deep brain stimulation of the centromedian nucleus of the thalamus for drug‐resistant epilepsy: A meta‐analysis and proposed programming framework

Epilepsia, EarlyView.
Abstract Objective Although the centromedian nucleus of the thalamus (CM) is an increasingly considered deep brain stimulation (DBS) target for drug‐resistant epilepsy (DRE), there is significant variability in programming practices, which may contribute to heterogenous outcomes.
Mohammed A. AlQahtani, Michal Stern‐Zimmer, Puneet Jain, Suvasini Sharma, Alfonso Fasano, Alexander Rotenberg, George M. Ibrahim, Carolina Gorodetsky   +7 more
wiley   +1 more source