Results 1 to 10 of about 10,024,591 (280)

Principal predictors of major adverse limb events in diabetic peripheral artery disease: A narrative review

Atherosclerosis Plus, 2021
Background and aims: The increasing prevalence of diabetes mellitus is causing a massive growth of peripheral artery disease incidences, a disabling complication of diabetic atherosclerosis, which leads often to the amputation of the affected limb ...
Federico Biscetti, Andrea Leonardo Cecchini, Maria Margherita Rando, Elisabetta Nardella, Antonio Gasbarrini, Massimo Massetti, Andrea Flex   +6 more
doaj   +4 more sources

Lipoprotein(a) and Risks of Peripheral Artery Disease, Abdominal Aortic Aneurysm, and Major Adverse Limb Events

Journal of the American College of Cardiology, 2023
BACKGROUND Lp(a) (lipoprotein[a])-lowering therapy to reduce cardiovascular disease is under investigation in phase 3 clinical trials. High Lp(a) may be implicated in peripheral artery disease (PAD), abdominal aortic aneurysms (AAAs), and major adverse ...
Peter E Thomas, Signe Vedel-Krogh, Børge G. Nordestgaard   +2 more
exaly   +3 more sources

PAD as a Marker of Systemic Atherosclerosis: A Comprehensive Review of Residual Risk and Contemporary Strategies for MACE and MALE Reduction [PDF]

Medicina
Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis associated with substantial risks of major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Scope: This comprehensive review examines the
Giuseppe Miceli, Maria Grazia Basso, Mariagiovanna Cuffaro, Antonino Marchese, Antonino Tuttolomondo   +4 more
doaj   +2 more sources

Apolipoprotein B100 predicts cardiovascular and limb events in type 2 diabetes patients with chronic limb-threatening ischemia [PDF]

Cardiovascular Diabetology
Background Patients with type 2 diabetes mellitus (T2DM) and chronic limb-threatening ischemia (CLTI) undergoing lower extremity revascularization (LER) face high risks of major adverse cardiovascular events (MACE) and major adverse limb events (MALE ...
Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex   +10 more
doaj   +2 more sources

Impact of comorbid depression on clinical outcomes in patients with peripheral artery disease: a systematic review and meta-analysis [PDF]

Frontiers in Cardiovascular Medicine
BackgroundDepression is a common comorbidity in cardiovascular disease; however, its prognostic impact in peripheral artery disease (PAD) remains uncertain.
Chuwen Chen, Lijia Wei, Jing Hu, Huanrui Hu, Bin Huang, Jichun Zhao, Wayne W. Zhang, Wayne W. Zhang, Wayne W. Zhang, Xiyang Chen   +9 more
doaj   +2 more sources

Risk stacking in peripheral artery disease (PAD): Integrating genetics, cardiometabolic disease and social determinants of health to explain worsening PAD outcomes [PDF]

International Journal of Cardiology. Cardiovascular Risk and Prevention
Peripheral artery disease (PAD) contributes disproportionately to disability, limb loss, and premature mortality, and U.S. major amputation rates have risen in the past decade among increasingly younger adults. Traditional risk tools incompletely explain
Matthew Nudy, Lawrence Sinoway, Faisal Aziz, Gerd Brunner   +3 more
doaj   +2 more sources

Association Between Intra-Leg Ankle-Brachial Index Asymmetry and Major Adverse Limb Events in Patients with Peripheral Artery Disease. [PDF]

J Clin Med
Background/Objectives: The ankle–brachial index (ABI) is the gold-standard test for peripheral artery disease (PAD). However, ABI is conventionally calculated using the higher of the dorsalis pedis (DP)- or posterior tibial (PT)-derived ankle pressure ...
Li B, Zakaria M, Zamzam A, AlQrain S, Göbölös L, Matrooshi NA, Abdin R, Qadura M.   +7 more
europepmc   +2 more sources

Comparative effectiveness of dual antiplatelet therapy after revascularization in diabetes and chronic limb-threatening ischemia: a target trial emulation study [PDF]

Cardiovascular Diabetology
Background Patients with diabetes and chronic limb-threatening ischemia (CLTI) face high risks of adverse limb and cardiovascular events. While post-revascularization dual antiplatelet therapy (DAPT) is generally recommended, the optimal regimen remains ...
Cheng-Wei Lin, Pi-Hua Liu, Chia-Hung Lin, Chung-Huei Huang, Shih-Yuan Hung, I-Wen Chen, Yi-Chia Chen, Yu-Yao Huang   +7 more
doaj   +2 more sources

Implications of Modest Reductions in ABI Measurements for Risk of Major Adverse Limb Events Among 223,350 Veterans. [PDF]

J Am Coll Cardiol
Background: Low resting ankle-brachial index (ABI) is a marker of poor cardiovascular outcomes. Whether modest decrements in ABI translate into higher risks of major adverse limb events (MALE) is unclear because prior studies are small or lack racial ...
Aday AW, Eden SK, Kundu S, Greevy RA, Anderson-Mellies A, Alba PR, Alcorn CW, Sullivan AE, Tindle HA, Beckman JA, Freiberg MS.   +10 more
europepmc   +2 more sources

Von Willebrand Factor and ADAMTS13 in Relation to Major Adverse Limb Events in Peripheral Artery Disease

Vascular Specialist International
Purpose: This study aimed to investigate the relationship between the two biomarkers, von Willebrand factor (VWF) and ADAMTS13, and major adverse limb events (MALE) in patients with peripheral artery disease (PAD). Materials and Methods : After obtaining
Noa Agid, Peter Andrisani, Hamzah Khan, Mohammad Qadura, Colin A. Kretz, Vinai C. Bhagirath   +5 more
doaj   +2 more sources